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Displaying results 1031 - 1040 of 10000 in total
  1. Drug

    Vardenafil

    go.drugbank.com/drugs/DB00862
    Approved

    [A258313] The use of vardenafil as a monotherapy for the treatment of pulmonary arterial hypertension has also been evaluated.[A258308] … Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.

    Categories: Drugs Used in Erectile Dysfunction, P-glycoprotein inhibitorsProducts: Vardenafil 1 A Pharma 5 mg - Filmtabletten, Vardenafil 1 A Pharma 10 mg - Filmtabletten
  2. Drug

    Daunorubicin

    go.drugbank.com/drugs/DB00694
    ApprovedInvestigational

    A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: (8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione, Leukaemomycin C
  3. Drug

    Insulin detemir

    go.drugbank.com/drugs/DB01307
    ApprovedInvestigational

    [A2358, A2359, A2360, A44] If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis … [A2358, A2359, A2360, A44] Insulin is also used in the treatment of Type 2 Diabetes (T2D), another form of diabetes mellitus that is a slowly progressing metabolic disorder caused by a combination of genetic

    Categories: Drugs Used in Diabetes, Cytochrome P-450 CYP1A2 InducersProducts: Levemir FlexPen 100U/ML Solution for injection in a prefilled pen, Levemir® FlexPen® 100 U/ml Solution for Injection in Pre-filled Pen
  4. Indication

    A History of Gastric or Duodenal Ulcers

    go.drugbank.com/conditions/DBCOND0090261
    Drugs: Lansoprazole
    Synonyms: A History of Gastric or Duodenal Ulcers
  5. Drug

    Riluzole

    go.drugbank.com/drugs/DB00740
    ApprovedInvestigational

    A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. … Riluzole is marketed as Rilutek by Sanofi.

    International brands: Xie Yi LiCategories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 Substrates
  6. Drug

    SIG-207

    go.drugbank.com/drugs/DB18547
    Experimental

    SIG-207 is a Cultured human retinal pigment epithelial cells (ARPE-19) genetically modified with a non-viral vector to express Human alpha-galactosidase A (alpha-Gal A), encapsulated within two-layer modified

  7. Drug

    SIG-007

    go.drugbank.com/drugs/DB17710
    Experimental

    SIG-007 is a gene therapy that consists of cells that are genetically modified with a non-viral vector to express human alpha-galactosidase A. … Developed by Sigilon Therapeutics, t is being investigated for the treatment of Fabry Disease.[L46153]

  8. Drug

    Temozolomide

    go.drugbank.com/drugs/DB00853
    ApprovedInvestigational

    [A229853, A229888, A229923, L32033] Following initial hydrolysis, further reactions liberate a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases … [L32033] Temozolomide was granted FDA approval on August 11, 1999, as an oral capsule and subsequently on February 27, 2009, as an intravenous injection.

    Synonyms: 3,4-dihydro-3-methyl-4-oxoimidazo(5,1-d)-as-tetrazine-8-carboxamide, 3-methyl-4-oxo-3,4-dihydroimidazo(5,1-d)(1,2,3,5)tetrazine-8-carboxamideCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein substrates
  9. Drug

    Ammonium lactate

    go.drugbank.com/drugs/DB06768
    Approved

    Ammonium lactate is the ammonium salt of lactic acid.

    Mixtures: Ultravate X, Ultravate XProducts: Lac-Hydrin, Lac Hydrin Cream
  10. Drug

    Daptomycin

    go.drugbank.com/drugs/DB00080
    ApprovedInvestigational

    Daptomycin is a cyclic lipopeptide antibacterial agent with a broad spectrum of activity against Gram-positive bacteria, including methicillin-susceptible and -resistant _Staphylococcus aureus_ (MSSA/MRSA … [A231384] Early work on developing daptomycin was abandoned due to observed myopathy but was resumed in 1997 when Cubist Pharmaceuticals Inc. licensed daptomycin; it was found that a once-daily dosing

    Categories: P-glycoprotein substratesProducts: CUBICIN® 350 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE, CUBICIN® 500 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE