Identification

Summary

Ammonium lactate is an inorganic compound used for the symptomatic treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.

Brand Names
Lac-hydrin, Ultravate X Ointment
Generic Name
Ammonium lactate
DrugBank Accession Number
DB06768
Background

Ammonium lactate is the ammonium salt of lactic acid.

Type
Small Molecule
Groups
Approved
Structure
Thumb
Weight
Average: 107.1085
Monoisotopic: 107.058243159
Chemical Formula
C3H9NO3
Synonyms
  • Ammonium (+-)-lactate
  • Ammonium lactate
  • Lactic acid ammonium salt
External IDs
  • E328

Pharmacology

Indication

For the treatment of dry, scaly skin (xerosis) and ichthyosis vulgaris and for temporary relief of itching associated with these conditions.

Pharmacology
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Associated Conditions
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Lactic acid is an alpha-hydroxy acid. It is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion.

Mechanism of action

Unknown.

Absorption

In vitro study of percutaneous absorption of ammonium lactate lotion, 12% using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours.

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Adverseeffects
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Toxicity

The oral administration of Lac-Hydrin to rats and mice showed this drug to be practically non-toxic (LD50 > 15 mL/kg).

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Products2
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Active Moieties
NameKindUNIICASInChI Key
Lactic acidunknown3B8D35Y7S450-21-5JVTAAEKCZFNVCJ-UHFFFAOYSA-N
International/Other Brands
Amlactin
Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Lac Hydrin CreamCream120 mg/1gTopicalSun Pharmaceutical Industries, Inc.2009-03-162014-02-28US flag
Lac-HydrinLotion120 mg/1gTopicalPhysicians Total Care, Inc.2008-08-152012-06-30US flag
Lac-HydrinLotion120 mg/1gTopicalSun Pharmaceutical Industries Limited2008-08-152008-08-15US flag
Lac-HydrinLotion120 mg/1gTopicalRanbaxy, Inc2008-01-28Not applicableUS flag
Lac-HydrinCream120 mg/1gTopicalBristol Myers Squibb Pharma Company2009-06-012012-10-15US flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Ammonium LactateCream12 g/100gTopicalPadagis Israel Pharmaceuticals Ltd2006-08-16Not applicableUS flag
Ammonium LactateLotion12 g/100gTopicalActavis Pharma, Inc.2012-06-052016-06-30US flag
Ammonium LactateCream12 g/100gTopicalbryant ranch prepack2006-08-16Not applicableUS flag
Ammonium LactateCream12 g/100gTopicalREMEDYREPACK INC.2019-11-25Not applicableUS flag
Ammonium LactateLotion12 g/100gTopicalbryant ranch prepack2006-06-20Not applicableUS flag
Ammonium LactateLotion12 g/100gTopicalPhysicians Total Care, Inc.2002-02-14Not applicableUS flag
Ammonium LactateLotion120 mg/1gTopicalTaro Pharmaceuticals U.S.A., Inc.2004-05-28Not applicableUS flag
Ammonium LactateLotion12 g/100gTopicalbryant ranch prepack2006-06-20Not applicableUS flag
Ammonium LactateCream120 mg/1gTopicalPaddock Laboratories, Inc.2006-02-072012-03-31US flag
Ammonium LactateLotion12 g/100gTopicalPadagis Israel Pharmaceuticals Ltd2006-06-20Not applicableUS flag
Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Ammonium LactateLotion17 g/1gTopicalNnodum Pharmaceuticals2007-12-30Not applicableUS flag
Ammonium LactateCream17 g/1gTopicalNnodum Pharmaceuticals2007-12-30Not applicableUS flag
Geri-HydrolacLotion12 g/100gTopicalGERITREX CORP2013-05-10Not applicableUS flag
Geri-HydrolacCream12 g/100gTopicalGERITREX CORP2013-06-25Not applicableUS flag
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
QuinosoneAmmonium lactate (120 mg/1g) + Mometasone furoate (1 mg/1g)KitTopicalV2 Pharma, LLC2019-06-03Not applicableUS flag
Ultravate XAmmonium lactate (100 mg/1g) + Ulobetasol propionate (0.5 mg/1g)KitTopicalSun Pharmaceutical Industries, Inc.2012-07-092017-08-31US flag
Ultravate XAmmonium lactate (100 mg/1g) + Ulobetasol propionate (0.50 mg/1g)KitTopicalRanbaxy Inc.2012-07-01Not applicableUS flag

Categories

Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as carboxylic acid salts. These are ionic derivatives of carboxylic acid.
Kingdom
Organic compounds
Super Class
Organic acids and derivatives
Class
Carboxylic acids and derivatives
Sub Class
Carboxylic acid derivatives
Direct Parent
Carboxylic acid salts
Alternative Parents
Secondary alcohols / Monocarboxylic acids and derivatives / Carboxylic acids / Organic zwitterions / Organic salts / Organic oxides / Organic nitrogen compounds / Hydrocarbon derivatives / Carbonyl compounds
Substituents
Alcohol / Aliphatic acyclic compound / Carbonyl group / Carboxylic acid / Carboxylic acid salt / Hydrocarbon derivative / Monocarboxylic acid or derivatives / Organic nitrogen compound / Organic oxide / Organic oxygen compound
Molecular Framework
Aliphatic acyclic compounds
External Descriptors
Not Available
Affected organisms
  • Humans and other mammals

Chemical Identifiers

UNII
67M901L9NQ
CAS number
515-98-0
InChI Key
RZOBLYBZQXQGFY-UHFFFAOYSA-N
InChI
InChI=1S/C3H6O3.H3N/c1-2(4)3(5)6;/h2,4H,1H3,(H,5,6);1H3
IUPAC Name
ammonium 2-hydroxypropanoate
SMILES
[NH4+].CC(O)C([O-])=O

References

General References
Not Available
Human Metabolome Database
HMDB0015671
KEGG Drug
D02920
PubChem Compound
62358
PubChem Substance
175427089
ChemSpider
56149
RxNav
215247
ChEMBL
CHEMBL1200747
PharmGKB
PA165958400
Wikipedia
Ammonium_lactate
FDA label
Download (14.2 KB)
MSDS
Download (46.8 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1
4CompletedTreatmentStable Plaque Psoriasis1
3CompletedTreatmentDry Skin1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamTopical12 g/100g
CreamTopical120 mg/1g
CreamTopical17 g/1g
LotionTopical12 g/100g
LotionTopical17 g/1g
LotionTopical120 mg/1g
KitTopical
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility866.0 mg/mLALOGPS
logP-0.51ALOGPS
logP-0.47ChemAxon
logS0.91ALOGPS
pKa (Strongest Acidic)3.78ChemAxon
pKa (Strongest Basic)-3.7ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area60.36 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity29.68 m3·mol-1ChemAxon
Polarizability7.65 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted ADMET Features
PropertyValueProbability
Human Intestinal Absorption+0.7873
Blood Brain Barrier+0.7656
Caco-2 permeable-0.7876
P-glycoprotein substrateNon-substrate0.7911
P-glycoprotein inhibitor INon-inhibitor0.9869
P-glycoprotein inhibitor IINon-inhibitor0.9581
Renal organic cation transporterNon-inhibitor0.952
CYP450 2C9 substrateNon-substrate0.8121
CYP450 2D6 substrateNon-substrate0.9016
CYP450 3A4 substrateNon-substrate0.7749
CYP450 1A2 substrateNon-inhibitor0.9606
CYP450 2C9 inhibitorNon-inhibitor0.9147
CYP450 2D6 inhibitorNon-inhibitor0.9687
CYP450 2C19 inhibitorNon-inhibitor0.9614
CYP450 3A4 inhibitorNon-inhibitor0.9755
CYP450 inhibitory promiscuityLow CYP Inhibitory Promiscuity0.9734
Ames testNon AMES toxic0.9357
CarcinogenicityNon-carcinogens0.5528
BiodegradationReady biodegradable0.9862
Rat acute toxicity1.5255 LD50, mol/kg Not applicable
hERG inhibition (predictor I)Weak inhibitor0.986
hERG inhibition (predictor II)Non-inhibitor0.9698
ADMET data is predicted using admetSAR, a free tool for evaluating chemical ADMET properties. (23092397)

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted GC-MS Spectrum - GC-MSPredicted GC-MSNot Available
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSNot Available
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSNot Available

Drug created at September 14, 2010 16:21 / Updated at February 21, 2021 18:52