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Tocopherol
go.drugbank.com/drugs/DB11251ApprovedInvestigationalThe different types of tocopherol can be presented trimethylated, dimethylated or methylated in the positions 5-, 7- and 8-. … Tocopherol, as a group, is composed of soluble phenolic compounds that consist of a chromanol ring and a 16-carbon phytyl chain.
Mixtures: Cernevit, Lyophilisate for ReconstitutionCategories: Compounds used in a research, industrial, or household setting, Vitamin EDaclatasvir
go.drugbank.com/drugs/DB09102ApprovedInvestigationalWithdrawnAccording to 2017 American Association for the Study of Liver Diseases (AASLD), 60mg of daclatasvir is recommended with 400mg [DB08934] for genotype 1a/b patients with or without cirrhosis as second-line … The therapy is intended to cure or achieve a sustained virologic response (SVR12), after 12 weeks of daily therapy.
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseDexrazoxane
go.drugbank.com/drugs/DB00380ApprovedInvestigationalWithdrawn[PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy. … It appears to inhibit formation of a toxic iron-anthracycline complex.
Categories: Compounds used in a research, industrial, or household setting, Detoxifying Agents for Antineoplastic TreatmentProducts: Dexrazoxane for InjectionAvatrombopag
go.drugbank.com/drugs/DB11995ApprovedInvestigational[F95] Avatrombopag was first approved by the FDA in May 2018 for use in adults with chronic liver disease who are scheduled to undergo a procedure. … [A33095] Thrombocytopenia is a common complication in patients suffering from chronic liver disease, occurring as a result of liver disease or a consequence of interferon-based antiviral therapy.
Resorcinol
go.drugbank.com/drugs/DB11085ApprovedInvestigationalResorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. … Although it is primarily indicated for use as a topical application, resorcinol also possesses a well-documented anti-thyroidal activity that is generally not relied upon for any kind of formal therapeutic
Categories: Anti-Acne Preparations for Topical UseNalmefene
go.drugbank.com/drugs/DB06230ApprovedInvestigationalWithdrawnNalmefene, a 6-methylene analogue of [naltrexone], is an opioid receptor antagonist. … [L1024] Nalmefene was approved in the United States in 1995 as an antidote for opioid overdose.[A245839] Nalmefene injection is used to manage known or suspected opioid overdose.
Categories: Heterocyclic Compounds with 4 or More Rings, Drugs Used in Alcohol DependenceAmiloride
go.drugbank.com/drugs/DB00594ApprovedInvestigationalAmiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705) … A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells.
Mixtures: Aa-amilzide, AMILORID HCT ALSynonyms: N-amidino-3,5-diamino-6-chloropyrazinecarboxamide, 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamideBendazac
go.drugbank.com/drugs/DB13501ApprovedWithdrawna small handful of regions may continue to have the medication available for purchase and use either as a topical anti-inflammatory/analgesic cream or eye drop formulation. … Bendazac, however, has since been withdrawn or discontinued in various international regions due to its capability or risk for eliciting hepatotoxicity [A39891, A39892, A39893, L4778] in patients although
Categories: Topical Products for Joint and Muscular Pain, Antiinflammatory Preparations, Non-Steroids for Topical UseCrovalimab
go.drugbank.com/drugs/DB16128ApprovedInvestigational[L50908] First developed by Chugai Pharmaceutical, in collaboration with Roche, crovalimab was first approved in China in February 2024 for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). … [L50933] Unlike other complement inhibitors previously approved for PNH, crovalimab uses a mechanism called anti-C5 sequential monoclonal antibody recycling technology that allows the drug to bind to
Padeliporfin
go.drugbank.com/drugs/DB15575ApprovedInvestigationalPadeliporfin is a water-soluble chlorophyll derivative and cytotoxic photosensitizer used for vascular-targeted photodynamic therapy for malignancies. … [A244559] Vascular-targeted photodynamic therapy (VTP), or vascular targeted photochemotherapy, is a focal treatment for localized prostate cancer.
Categories: Heterocyclic Compounds with 4 or More Rings, Sensitizers Used in Photodynamic/radiation Therapy