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Eph receptors
go.drugbank.com/bio_entities/BE0028186TargetHumansReceptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5 … Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3.
Polypeptides: Ephrin type-A receptor 1, Ephrin type-A receptor 10Synonyms: Tyrosine-protein kinase receptor EPH, Tyrosine-protein kinase receptor ECKGinsenoside Rb1
go.drugbank.com/drugs/DB06749ExperimentalNutraceuticalRecent research shows that Rb1 affects rat embryo development and has teratogenic effects, causing birth defects.
Glycine receptors
go.drugbank.com/bio_entities/BE0009666TargetHumansSubunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contri...
Synonyms: Glycine receptor 48 kDa subunit, Glycine receptor 58 kDa subunitPolypeptides: Glycine receptor subunit alpha-1, Glycine receptor subunit betaPalovarotene
go.drugbank.com/drugs/DB05467ApprovedTreatment options for patients with FOP are extremely limited, although there has been substantial recent interest in novel treatments for this disease. … [A244920] Palovarotene is a selective agonist of retinoic acid receptor gamma (RARγ) belonging to a class of medications known as retinoids, similar in mechanism to drugs like [tazarotene] or [trifarotene
Categories: Retinoic Acid Receptor gamma, agonistsKainate receptors
go.drugbank.com/bio_entities/BE0009793TargetHumansThe receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist … Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid.
Polypeptides: Glutamate receptor ionotropic, kainate 1, Glutamate receptor ionotropic, kainate 2Synonyms: Glutamate receptor 5, Glutamate receptor 6Tobramycin
go.drugbank.com/drugs/DB00684ApprovedInvestigationalAminoglycosides, many of which are derived directly from Streptomyces spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms. Inhaled tobramycin is n...
RG2417
go.drugbank.com/drugs/DB05055InvestigationalRecent reports indicate that certain genes that encode for mitochondrial proteins are significantly down regulated in the brains of bipolar patients.
Human Retinoid X Receptors (RXRs)
go.drugbank.com/bio_entities/BE0010096TargetHumansReceptor for retinoic acid. … Receptor for retinoic acid.
Polypeptides: Retinoic acid receptor RXR-alpha, Retinoic acid receptor RXR-betaSynonyms: Retinoid X receptor alpha, Retinoid X receptor betaPeroxisome proliferator-activated receptors
go.drugbank.com/bio_entities/BE0010120TargetHumans and other mammalsReceptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. … Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids.
Polypeptides: Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor deltaSynonyms: Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 1Prostaglandin E2 Receptors
go.drugbank.com/bio_entities/BE0010100TargetHumansReceptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. … Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system.
Polypeptides: Prostaglandin E2 receptor EP1 subtype, Prostaglandin E2 receptor EP2 subtypeSynonyms: PGE receptor EP1 subtype, Prostanoid EP1 receptor