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Nogapendekin alfa
go.drugbank.com/drugs/DB18740ApprovedInvestigational[A263617, A263622] Nogapendekin alfa, in combination with inbakicept, mimics the actions of IL-15, , stimulating the activation and proliferation of natural killer cells and CD8+ memory T cells, which … [L50627] Non-muscle invasive bladder cancer (NMIBC), which accounts for 75% of all bladder tumours, is commonly treated with transurethral resection of the bladder tumour and Bacillus Calmette-Guérin (
Categories: Amino Acids, Peptides, and Proteins, Intercellular Signaling Peptides and ProteinsSynonyms: Fusion protein consisting of il-15n72d and il-15rasu/fc, Il-15n72d:il-15rec-su/fc soluble complex iGoflikicept
go.drugbank.com/drugs/DB16396InvestigationalGoflikicept is under investigation in clinical trial NCT04380519 (Study of the Efficacy and Safety of a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe … Acute Respiratory Syndrome Coronavirus 2 (Sars-cov-2) Infection (COVID-19)).
Categories: Antineoplastic and Immunomodulating AgentsSynonyms: Heterodimeric fusion protein that binds to IL-1 beta consisting of human extracellular domain of IL1 receptor and a mutant Fc fragment of human IGg1 and part of human IL1 receptor accessory proteinCHF5633
go.drugbank.com/drugs/DB18696InvestigationalCHF5633 is a fully synthetic pulmonary surfactant preparation comprising DPPC (dipalmitoylphosphatidylcholine), POPG Na (palmitoyl‐oleoyl‐phosphatidylglycerol sodium), a synthetic SP-C analogue, and a … synthetic SP-B analogue.
Categories: Amino Acids, Peptides, and ProteinsSynonyms: Synthetic surfactant comprised of DPPC, POPG Na, synthetic SP-C analogue and synthetic SP-B analogueDCVAC/OvCa
go.drugbank.com/drugs/DB18571InvestigationalDCVAC/OvCa is a therapy comprising autologous dendritic cells pulsed with killed ovarian cancer cells and matured by TLR3 ligand _ex vivo_. … It is under investigation for the treatment of ovarian cancer.
Synonyms: Autologous dendritic cells pulsed with killed ovarian cancer cells and matured by TLR3 ligand ex vivoStreptococcus salivarius
go.drugbank.com/drugs/DB19274InvestigationalSynonyms: Streptococcus salivarius andrewes and horder, 1906Topiramate
go.drugbank.com/drugs/DB00273ApprovedInvestigationalTopiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996. … [L10550] Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen.
Mixtures: Phentermine and topiramate, Phentermine and topiramateCategories: Alimentary Tract and Metabolism, phentermine and topiramateHesperidin
go.drugbank.com/drugs/DB04703ApprovedInvestigationalHesperidin is a flavan-on glycoside found in citrus fruits.
Mixtures: VENAFIX (Diosmin and Hesperidin Tablet), Venafix DS Diosmin 900mg and Hesperidin 100mg TabletsCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingTPX-4589
go.drugbank.com/drugs/DB18604InvestigationalTPX-4589 is an antibody-drug conjugate composed of a humanized monoclonal antibody targeting CLDN18.2 and linker-payload MC-VC-PAB-MMAE.
Synonyms: Antibody drug conjugate composed of a humanized monoclonal antibody targeting CLDN18.2 and linker-payload MC-VC-PAB-MMAEARGX-119
go.drugbank.com/drugs/DB18133InvestigationalARGX-119 is a monoclonal antibody that targets and activates muscle-specific kinase (MuSK).
Synonyms: a fully humanized immunoglobulin gamma 1 (IgG1) agonistic monoclonal antibody (mAb) that specifically targets and activates MuSKGTP-506
go.drugbank.com/drugs/DB17682ExperimentalGTP-506 is a gene therapy formed by two vectors, a nuclease vector targeting gene editing in the well-characterized PCSK9 gene locus and a therapeutic donor vector that inserts the OTC gene to provide
Synonyms: Non-replicating recombinant adeno-associated virus serotype rh79 (AAVrh.79) vectors: AAVrh79.TBG.M2PCSK9.WPRE.bGH and AAVrh79.hHDR.TBG.hOTCco.bGH