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Entrectinib
go.drugbank.com/drugs/DB11986ApprovedInvestigational[L8081] It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors. … This therapy offers benefit over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib] due to a wider range of targets.[A183929]
Synonyms: N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(oxan-4-ylamino)benzamideCategories: Antineoplastic and Immunomodulating AgentsUpadacitinib
go.drugbank.com/drugs/DB15091ApprovedInvestigationalIt is characterized by synovial inflammation and hyperplasia, autoantibody production, cartilage damage and bone destruction, leading to co-morbidities. … [L10896] In December 2019, it was additionally approved by the European Commission and Health Canada.[L10899,L42540] Upadacitinib is marketed under the brand name RINVOQ for oral administration.
Categories: Antineoplastic and Immunomodulating AgentsProducts: RINVOQ EXTENDED-RELEASE TABLET 15MG, RINVOQ 15mg Extended Release Film Coated TabletsEgg yolk
go.drugbank.com/drugs/DB10530ApprovedEgg yolk allergenic extract is used in allergenic testing.
Categories: Non-Standardized Food Allergenic ExtractProducts: Food - Animal Products and Poultry Products, Egg, Yolk Gallus sp.Dihydro-alpha-ergocryptine
go.drugbank.com/drugs/DB11274ApprovedAlpha-dihydroergocryptine is usually referred to the mixture of the alpha and beta dihydroergocryptine. These two compounds are differentiated in the position of a methyl group. … Alpha-dihydroergocryptine approved drug product is as a part of an ergoloid mixture. To know more about this mixture, please visit [DB01049]
Products: ALMIRID CRIPAR 20MG, ALMIRID CRIPAR 40MGCarbopol 974P
go.drugbank.com/drugs/DB05384ApprovedWithdrawnIt was under development by ReProtect LLC. It is a gel that may help both block the spread of sexually transmitted diseases and reduce unwanted pregnancies. … The compound, known as BufferGel, was in advanced clinical trials for its ability to prevent pregnancy, but was discontinued.
Products: LIQUIGEL UD 2.5MG/G EINZELLevobupivacaine
go.drugbank.com/drugs/DB01002ApprovedInvestigationalWithdrawnto an anesthetic. … It is approximately 13 per cent less potent (by molarity) than racemic bupivacaine.Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal
Products: COZELTI ICEREN 10ML X 10 AMPUL, COZELTI ICEREN 10ML X 10 AMPULRhizopus stolonifer
go.drugbank.com/drugs/DB10814ApprovedRhizopus stolonifer is a fungus which can provoke allergic reactions. Rhizopus stolonifer extract is used in allergenic testing.
Categories: Non-Standardized Fungal Allergenic ExtractProducts: Molds, Rusts and Smuts, Rhizopus nigricansOcrelizumab
go.drugbank.com/drugs/DB11988ApprovedInvestigationalIt was later approved by Health Canada in August 2017, making the drug the first available treatment for PPMS in both the US and Canada. … [L1199] In phase 3 clinical trials of patients with PPMS, treatment with ocrelizumab led to lower clinical and MRI progression rates compared to placebo.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: OCREVUS 300mg/10mL Concentrate for Solution for Infusion, OCREVUS® CONCENTRADO PARA SOLUCION PARA INFUSION 300MG/10MLAcetylcysteine
go.drugbank.com/drugs/DB06151ApprovedInvestigationalAcetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose. … [A228158,A228163,A228168] Acetylcysteine was granted FDA approval on 14 September 1963.[L31488]
Mixtures: Levomefolate Calcium Acetylcysteine and Mecobalamin Algal, Levomefolate Calcium, Acetylcysteine, Mecobalamin and AlgalCategories: Cough and Cold Preparations, Amino Acids, Peptides, and ProteinsNitroprusside
go.drugbank.com/drugs/DB00325ApprovedInvestigationalNitroprusside serves as a source of nitric oxide, a potent peripheral vasodilator that affects both arterioles and venules (venules more than arterioles). … Nitroprusside is often administered intravenously to patients who are experiencing a hypertensive emergency.
Categories: Nitrates and Nitrites, Indicators and ReagentsProducts: NITROPRUSIATO DE SODIO USP 25MG/ML, N-PRUS