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Sphingosine
go.drugbank.com/drugs/DB03203InvestigationalAn amino alcohol with a long unsaturated hydrocarbon chain. Sphingosine and its derivative sphinganine are the major bases of the sphingolipids in mammals. (Dorland, 28th ed)
Categories: P-glycoprotein substratesSetileuton
go.drugbank.com/drugs/DB19550InvestigationalSetileuton is a small molecule drug. The usage of the INN stem '-leuton' in the name indicates that Setileuton is a 5-lipo-oxygenase inhibitor, anti-inflammatory. Setileuton is under investigation in clinical trial NCT00404313 (The Effec...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesMifentidine
go.drugbank.com/drugs/DB19721ExperimentalMifentidine is a small molecule drug. The usage of the INN stem '-tidine' in the name indicates that Mifentidine is a histamine- H2-receptor antagonist, cimetidine derivative. Mifentidine has a monoisotopic molecular weight of 228.14 Da.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsLefetamine
go.drugbank.com/drugs/DB19944ExperimentalLefetamine is a small molecule drug. Lefetamine has a monoisotopic molecular weight of 225.15 Da.
Categories: Cytochrome P-450 CYP1A2 Substrates, Cytochrome P-450 SubstratesTauromustine
go.drugbank.com/drugs/DB19978ExperimentalTauromustine is a small molecule drug. The usage of the INN stem '-mustine' in the name indicates that Tauromustine is a antineoplastic, alkylating agent, (β-chloroethyl) amine derivative. Tauromustine has a monoisotopic molecular weight...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C19 SubstratesEthiodized oil
go.drugbank.com/drugs/DB00965ApprovedInvestigationalEthiodized oil is used by injection as a radio-opaque contrast agent. The composition of the oil is comprised of iodine combined with ethyl esters of fatty acids of poppyseed oil. And although these esters are primarily as ethyl monoiodo...
Arsenic trioxide
go.drugbank.com/drugs/DB01169ApprovedInvestigationalArsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic ...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsNadolol
go.drugbank.com/drugs/DB01203ApprovedInvestigationalNadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure. Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal r...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesInsulin aspart
go.drugbank.com/drugs/DB01306ApprovedInvestigationalAs a result, people with T1D rely primarily on exogenous forms of insulin, such as insulin aspart, to lower glucose levels in the blood. … Saccharomyces cerevisiae_ (baker's yeast) Without an adequate supply of insulin to promote absorption of glucose from the bloodstream, blood sugar levels can climb to dangerously high levels and can result
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersInsulin detemir
go.drugbank.com/drugs/DB01307ApprovedInvestigational[A2358, A2359, A2360, A44] As a result, people with T1D rely primarily on exogenous forms of insulin, such as insulin detemir, to lower glucose levels in the blood. … [A2358, A2359, A2360, A44] Without an adequate supply of insulin to promote absorption of glucose from the bloodstream, blood sugar levels can climb to dangerously high levels and can result in symptoms
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme Inducers