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Nortriptyline
go.drugbank.com/drugs/DB00540ApprovedInvestigational[L11878] It is used in the treatment of major depression and is also used off-label for chronic pain and other conditions.[L11881]
Categories: Antidepressive Agents Indicated for DepressionAfatinib
go.drugbank.com/drugs/DB08916ApprovedInvestigationalFor oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal growth factor receptor (EGFR) mutations as detected … Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label].
Tetracycline
go.drugbank.com/drugs/DB00759ApprovedInvestigationalVet approvedWithdrawnThe FDA withdrew its approval for the use of all liquid oral drug products formulated for pediatric use containing tetracycline in a concentration greater than 25 mg/ml.
Categories: Antibiotics for Topical Use, Antibacterials for Systemic UseDuvelisib
go.drugbank.com/drugs/DB11952ApprovedInvestigationalAll the work around duvelisib showed that this agent is a potent inhibitor of both forms.[A39025] Duvelisib was developed by Verastem, Inc and FDA approved on September 24, 2018.[L4585]
Selinexor
go.drugbank.com/drugs/DB11942ApprovedInvestigationalOther chemotherapies for multiple myeloma include [lenalidomide] and [dexamethasone], [thalidomide], and may include [melphalan] if the patient is not eligible for transplant. … [L7123] Selinexor was also granted accelerated approval for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) that have gone through at least 2 lines of
Melphalan flufenamide
go.drugbank.com/drugs/DB16627ApprovedWithdrawn[A230123] The increased potency makes melphalan flufenamide a treatment option for patients with relapsed or refractory multiple myeloma who have attempted at least 4 lines of therapy already. … Melphalan flufenamide, also known as melflufen or J1, is a prodrug of [melphalan].
Tavaborole
go.drugbank.com/drugs/DB09041ApprovedTavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis of ATP-dependent ligation of L-leucine to tRNA(Leu). … Tavaborale is a novel, boron-based topical antifungal medication for the treatment of onychomycosis, a fungal infection of the nail and nail bed due to *Trichophyton rubrum* or *Trichophyton mentagrophytes
Categories: Antifungals for Topical Use, Antifungals for Dermatological UseProguanil
go.drugbank.com/drugs/DB01131ApprovedProguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofo...
Categories: chloroquine and proguanilEncorafenib
go.drugbank.com/drugs/DB11718ApprovedInvestigationalEncorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. … [L3344] On June 27, 2018, the Food and Drug Administration approved encorafenib and [binimetinib] (BRAFTOVI and MEKTOVI, Array BioPharma Inc.) in combination for patients with unresectable or metastatic
Black cohosh
go.drugbank.com/drugs/DB13975Approved[A32543] The American College of Obstetrics and Gynecology guidelines on the use of botanicals, such as black cohosh, for the management of menopausal symptoms the use of for up to six months, especially … Historical names for this plant include snakeroot, black bugbane, rattleweed, macrotys, and rheumatism weed. Black cohosh has a long history of use.
Mixtures: Menopause Relief for Women