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Spironolactone
go.drugbank.com/drugs/DB00421ApprovedInvestigationalSpironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. … [A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243]
Mixtures: Benzoyl Peroxide 5% / Clindamycin 1% / Niacinamide 2% / Spironolactone 2%, Dapsone 6% / Niacinamide 2% / Spironolactone 5%Categories: P-glycoprotein inducers, Cytochrome P-450 CYP2C8 InhibitorsErgoloid mesylate
go.drugbank.com/drugs/DB01049Approved[L2639]Later in 1991, the mixture of ergoloid mesylates was retaken by Sun Pharmaceutical Industries and approved by the FDA. … Ergoloid Mesylate is an equiproportional preparation of three different ergotamantriones: dihydroergocornine, dihydroergocristine, and dihydroergocryptine.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: Hydergine LC, อินเดอร์จิน 1 มก.Anastrozole
go.drugbank.com/drugs/DB01217ApprovedInvestigational[L8863] Anastrozole is also related to [exemestane], a steroidal AI, but its non-steroidal nature provides stark advantages including a lack of steroid-associated adverse effects such as weight gain and … Anastrozole is a non-steroidal aromatase inhibitor (AI), similar to [letrozole], used to decrease circulating estrogen levels in the treatment of postmenopausal women with estrogen-responsive breast cancer
Synonyms: α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrileCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesOlopatadine
go.drugbank.com/drugs/DB00768ApprovedIt is a structural analog of [doxepin], which has a minimal anti-allergic activity. … [A1172] In comparison to other anti-allergenic ophthalmic medications, olopatadine displays a good comfort and tolerability profile since it does not cause perturbation of cell membranes.
Mixtures: OFNOL FRESH % 0.1 + %0.15 STERİL OFTALMİK ÇÖZELTİ, 1 ADETCategories: Cytochrome P-450 Substrates, P-glycoprotein substratesDacarbazine
go.drugbank.com/drugs/DB00851ApprovedInvestigationalAn antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). … Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Categories: Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2E1 Substrates with a Narrow Therapeutic IndexSynonyms: 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide, 4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamideTilactase
go.drugbank.com/drugs/DB13761ApprovedInvestigationalTilactase is a beta-D-galactosidase obtained from _Aspergillus oryzae_. It is produced as a chewable tablet that has to be taken before the consumption of a lactose-containing meal. … [A27172] The beta-D-galactosidase us a large monomeric multi-domain enzyme of 985 residues that presents a catalytic (alpha/beta)8-barrel domain.
Synonyms: beta-D-GalactosidaseProducts: Lactase Enzyme Tablets 3300 Lac Units, LACDIGEST 2250 U CIGNEME TABLETI, 100 TABLETNimesulide
go.drugbank.com/drugs/DB04743ApprovedWithdrawnNimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. … Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in many countries.
Mixtures: NIMOKAIN %1 + %5 JEL, 50 G, SULIDIN PLUS %1 + %5 LIKIT JEL, 30 GCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesEpoprostenol
go.drugbank.com/drugs/DB01240ApprovedInvestigationalA prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue.
Categories: Prostaglandins ISynonyms: Prostaglandin X, (5Z,9α,11α,13E,15S)-6,9-epoxy-11,15-dihydroxyprosta-5,13-dien-1-oic acidInvasive Meningococcal Disease caused by Neisseria meningitidis serogroup A
go.drugbank.com/conditions/DBCOND0165273Drugs: Meningococcal (groups A, C, Y and W-135) oligosaccharide diphtheria CRM197 conjugate vaccine · Meningococcal polysaccharide vaccine group A · Neisseria meningitidis group A capsular polysaccharide tetanus toxoid conjugate antigen · Neisseria meningitidis group a capsular polysaccharide diphtheria toxoid conjugate antigenSynonyms: Invasive Infection caused by Neisseria meningitidis serogroup A, Invasive Meningococcal Disease caused by Neisseria meningitidis serogroup APreviously treated with a Bruton tyrosine kinase (BTK) inhibitor
go.drugbank.com/conditions/DBCOND0165389Synonyms: Previously treated with a Bruton tyrosine kinase (BTK) inhibitor