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Displaying results 111 - 120 of 58360 in total
  1. Drug

    Temozolomide

    go.drugbank.com/drugs/DB00853
    ApprovedInvestigational

    [A229853, A229888, A229923, L32033] Following initial hydrolysis, further reactions liberate a highly reactive methyl diazonium cation capable of methylating various residues on adenosine and guanine bases

    Categories: P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: GLIOTEM 100 CAPSULE 100 MG, TEMITOMA 140 MG
  2. Drug

    Estradiol

    go.drugbank.com/drugs/DB00783
    ApprovedInvestigationalVet approved

    Estradiol is a naturally occurring hormone circulating endogenously in females. … Because it has a low oral bioavailability on its own, estradiol is commonly formulated with an ester side-chain.

    Synonyms: (17β)-estra-1,3,5(10)-triene-3,17-diol, 17β-estra-1,3,5(10)-triene-3,17-diolInternational brands: Estraderm MX
  3. Drug

    Medroxyprogesterone acetate

    go.drugbank.com/drugs/DB00603
    ApprovedInvestigational

    Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties.

    Mixtures: DIVINA 2 MG + 2 MG /10 MG TABLET, 21 ADET, DIVICONT TABLETAS 1 MG/5 MGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Inducers
  4. Drug

    Rivaroxaban

    go.drugbank.com/drugs/DB06228
    ApprovedInvestigational

    However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. … Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary.

    Categories: Factor Xa Inhibitors, Direct factor Xa inhibitorsProducts: Rivaroxaban 1A Pharma 15 mg – Filmtabletten, Rivaroxaban 1A Pharma GmbH 15 mg – Filmtabletten
  5. Drug

    Pipotiazine

    go.drugbank.com/drugs/DB01621
    ApprovedInvestigationalWithdrawn

    However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. … Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsProducts: PIPORTIL ® L-4SOLUCION INYECTABLE AL 2.5% (100 MG)., TRIPIPOT® SOLUCIÓN INYECTABLE 25 MG/ML
  6. Drug

    Itraconazole

    go.drugbank.com/drugs/DB01167
    ApprovedInvestigational

    First synthesized in the early 1980s, itraconazole is a broad-spectrum triazole antifungal agent used to treat a variety of infections. … [A34257] It is a 1:1:1:1 racemic mixture of four diastereomers, made up of two enantiomeric pairs, each possessing three chiral centers.

    Mixtures: ITRACONAZOL 33.3 MG + SECNIDAZOL 166.66 MG CÁPSULACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 Inhibitors
  7. Drug

    Nizatidine

    go.drugbank.com/drugs/DB00585
    Approved

    A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.

    Products: AXID CAPSULAS 150 MG, NIZAX CAPSULAS 150 MG
  8. Drug

    Nimesulide

    go.drugbank.com/drugs/DB04743
    ApprovedInvestigationalWithdrawn

    Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties.

    Mixtures: ETNA COMBO 100 MG/8 MG TABLET, 14 ADET, NİMES COMBO 100 MG / 8 MG TABLET , 14 ADETCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  9. Drug

    Levothyroxine

    go.drugbank.com/drugs/DB00451
    ApprovedInvestigational

    Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. … [F4633] Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient

    Mixtures: BITIRON 50 MCG/12.5 MCG TABLET, 100 ADET, SYNTHROID® 112 MCG TABLETASCategories: UGT1A1 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Inhibitors
  10. Drug

    Cenobamate

    go.drugbank.com/drugs/DB06119
    ApprovedInvestigational

    [A188442,L10653] The exact mechanism of action has not been described in the literature, though it positively modulates GABA<sub>A</sub> and inhibits voltage gated sodium channels.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersProducts: XCOPRI MAINTENANCE PACK 100 mg, 150 mg, XCOPRI TITRATION PACK 150 mg, 200 mg