Search
Infigratinib
go.drugbank.com/drugs/DB11886ApprovedInvestigationalWithdrawn[A235174] On May 28, 2021, the FDA granted accelerated approval to infigratinib - under the market name Truseltiq - for the treatment of previously treated, unresectable locally advanced or metastatic … [L34304] The FDA later announced the final withdrawal of the approval of infigratinib for this indication on May 16, 2024: This decision was based on the sponsor's request due to clinical trial recruitment
Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitorsDoconexent
go.drugbank.com/drugs/DB03756ApprovedInvestigationalIt is an omega-3 fatty acid and primary structural component of the human brain, cerebral cortex, skin, and retina thus plays an important role in their development and function. … It can be biosythesized from alpha-linolenic acid or commercially manufactured from microalgae.
Mixtures: Se-Tan DHA, Se-Tan DHACategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 InhibitorsMomelotinib
go.drugbank.com/drugs/DB11763ApprovedInvestigationalMF includes primary MF (PMF), post-polycythemia vera (PV) MF, and post-essential thrombocythemia (ET) MF. Clinical manifestations of MF include anemia and thrombocytosis.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesCasimersen
go.drugbank.com/drugs/DB14984ApprovedInvestigational[A218186] Casimersen is the most recent in a line of approved PMOs for treating DMD, including [eteplirsen] and [viltolarsen]. … [A218171, A218176, A229988] The application of antisense oligonucleotides in DMD patients with specific mutations allows for exon skipping to produce truncated BMD-like dystrophin proteins, which restore
Categories: Cytochrome P-450 CYP2C19 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsCilazapril
go.drugbank.com/drugs/DB01340ApprovedInvestigationalIt is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. … It is branded as Inhibace in Canada and other countries, Vascace and Dynorm in a number of European countries, among many other names. None of these varieties are available in the United States.
Categories: P-glycoprotein inhibitors, Antihypertensive Agents Indicated for HypertensionPibrentasvir
go.drugbank.com/drugs/DB13878ApprovedInvestigationalAs of June 2025, the FDA approved an expanded indication for Mavyret, making it the first and only direct-acting antiviral therapy approved for the treatment of both acute and chronic HCV in patients aged … Mavyret is also indicated for HCV genotype 1-infected patients who have been previously treated with regimens either containing an NS5A inhibitor or an NS3/4A protease inhibitor, but not both [L940].
Categories: Antivirals for Systemic Use, Antiinfectives for Systemic UseCalcium citrate
go.drugbank.com/drugs/DB11093ApprovedInvestigationalCalcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.
Mixtures: Cal-mag With Vitamin D, Calcium and Mag-potass and Zinc CapNaloxone
go.drugbank.com/drugs/DB01183ApprovedInvestigationalVet approvedHowever, for individuals using opioid medications or experiencing an overdose, IM injection of naloxone rapidly reverses opioid effects and can cause the injected individual to immediately experience withdrawal … [A234594] More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, causing the rapid removal of any other drugs bound to these receptors.
Mixtures: TILIDIN 100/8 RETARD 1A PH, TILIDIN 100/8 RETARD 1A PHCategories: Drugs for Constipation, Peripheral Opioid Receptor AntagonistsHormone Receptor Positive Metastatic Breast Cancer
go.drugbank.com/conditions/DBCOND0120563Synonyms: Hormone Receptor-positive Metastatic Breast Cancer, Hormone Receptor Positive Metastatic Breast CancerAcellular nerve allograft
go.drugbank.com/drugs/DB30293ApprovedInvestigationalApproved by the FDA under a Biologics License Application (BLA) as an acellular nerve scaffold for the treatment of adult and pediatric patients (aged ≥1 month) with sensory, mixed, and motor peripheral … Our team is working on the full update, which will be available soon. [L54673,L54668]