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Fentanyl
go.drugbank.com/drugs/DB00813ApprovedIllicitInvestigationalVet approvedFentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. … Fentanyl's high potency has also made it a common adulterant in illicit drugs, especially heroin.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: N-phenyl-N-(1-(2-phenylethyl)-4-piperidinyl)propanamide, N-phenyl-N-[1-(2-phenylethyl)-4-piperidinyl]propanamideLamotrigine
go.drugbank.com/drugs/DB00555ApprovedInvestigational[A191350] Lamotrigine has relatively few side-effects and does not require laboratory monitoring. … Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder.
Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, P-glycoprotein inhibitorsSynonyms: 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazineFlecainide
go.drugbank.com/drugs/DB01195ApprovedInvestigationalWithdrawnFlecainide is a Class I anti-arrhythmic agent like [encainide] and [propafenone]. … [A186880] Flecainide’s development began in 1966 and was first synthesized in 1972 as an attempt to generate new anesthetics.
Categories: MATE 1 Substrates with a Narrow Therapeutic Index, P-glycoprotein substrates with a Narrow Therapeutic IndexSynonyms: N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamideCabazitaxel
go.drugbank.com/drugs/DB06772ApprovedInvestigationalCabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. … [A260621] As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic IndexSynonyms: 1-HYDROXY-7.BETA.,10.BETA.-DIMETHOXY-9-OXO-5.BETA.,20-EPOXYTAX-11-ENE-2.ALPHA.,4,13.ALPHA.-TRIYL 4-ACETATE 2-BENZOATE 13-((2R,3S)-3-(((TERT-BUTOXY)CARBONYL)AMINO)-2-HYDROXY-3-PHENYLPROPANOATE)Cholestyramine
go.drugbank.com/drugs/DB01432ApprovedInvestigationalCholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins.
Categories: Compounds used in a research, industrial, or household settingProducts: ANTILIP GRANULADO EN SACHET, COLESTIRAMINA 4 G.Colloidal oatmeal
go.drugbank.com/drugs/DB11286ApprovedNutraceuticalIt is available in topical products as a skin soothing agent. … Colloidal oatmeal is a FDA-approved skin protectant that temporarily protects and helps relieve minor skin irritation and itching due to rashes, eczema, poison ivy, oak, sumac, or insect bites.
Mixtures: Pediadermics Eczema 3, 5% Oat Facial CleanserProducts: A Bit Hippy, Dht XDesvenlafaxine
go.drugbank.com/drugs/DB06700ApprovedInvestigational[L6016,A261271] MDD is a highly prevalent psychiatric disorder, with a lifetime prevalence estimate of 16% in the US alone and 12.8% in Europe. … [A261271] Desvenlafaxine has a very similar pharmacological, efficacy, and safety profile as [venlafaxine].
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsSynonyms: O-desmethylvenlafaxineBudesonide
go.drugbank.com/drugs/DB01222ApprovedInvestigationalBudesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis. … [L10598] It is also available in a combination product with [formoterol].[L10619]
Mixtures: BUDESONIDE E FORMOTEROLO SANDOZ, BUDESONIDE E FORMOTEROLO SANDOZCategories: P-glycoprotein substrates, Cytochrome P-450 SubstratesBromazepam
go.drugbank.com/drugs/DB01558ApprovedIllicitIt is a Schedule IV drug in the U.S. and Canada and under the Convention on Psychotropic Substances. It is a intermediate-acting benzodiazepine.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: BROMAZEPAM EG, BROMAZEPAM AL 6Oxycodone
go.drugbank.com/drugs/DB00497ApprovedIllicitInvestigationalOxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. … for an extended period.
Mixtures: OSSICODONE E NALOXONE EG, OSSICODONE E NALOXONE EGCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates