Desvenlafaxine is an antidepressant agent and SNRI used for the treatment of major depressive disorders in adults. Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of venlafaxine.
- Mechanism
- Curator reviewed · 2 references
The exact mechanism of the antidepressant action of desvenlafaxine is unknown but is thought to be related to the potentiation of serotonin and norepinephrine in the central nervous system, through inhibition of their reuptake. Particularly, desvenlafaxine has been found to inhibit the serotonin, norepinephrine, and dopamine transporters with varying degrees of affinity. Desvenlafaxine inhibits serotonin transporters with 10 times the affinity of norepinephrine transporters, and dopamine transporters with the lowest affinity.
- Primary indication
- Desvenlafaxine is indicated for the treatment of major depressive disorder in adults.Curator reviewed · 2 structured indications
- Formula / weight
- C16H25NO2 · 263.3752 g/mol (avg)
- First approval
- Canada, 2014 · United States, 2008
- Code names
- DVS 233
- Brand names
Resolves to
KYYIDSXMWOZKMP-UHFFFAOYSA-NSMILESCN(C)CC(C1=CC=C(O)C=C1)C1(O)CCCCC1What you can answer from here — as of September 30, 2026
Which drugs share a target with Desvenlafaxine, and which of those have an active Phase 3 trial?
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