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Displaying results 1281 - 1290 of 2256 in total
  1. Drug

    Vosoritide

    go.drugbank.com/drugs/DB11928
    ApprovedInvestigational

    Endogenous CNP, first described in 1998, is primarily responsible for the stimulation of chondrocytes and long bone growth via activity at the NPR-B receptor, making it an attractive target in the treatment

  2. Indication

    Triple-Negative Breast Cancer

    go.drugbank.com/conditions/DBCOND0068542
    Drugs: Atezolizumab
    Synonyms: Breast Carcinoma That is Estrogen Receptor, Progesterone Receptor, and Her2 Negative
  3. Drug

    Sparsentan

    go.drugbank.com/drugs/DB12548
    ApprovedInvestigational

    Sparsentan is a dual antagonist of the endothelin type A receptor (ET<sub>A</sub>R) and the angiotensin II (Ang II) type 1 receptor (AT<sub>1</sub>R) with a similar affinity for both (9.3 nM for ET<sub

    Categories: Angiotensin 2 Receptor Blocker, Dual Endothelin Type A Receptor/Ang II Subtype 1 Receptor Antagonist (DEARA)
  4. Drug

    Testosterone undecanoate

    go.drugbank.com/drugs/DB13946
    ApprovedInvestigational

    [L35970] It was developed via fatty acid esterification of testosterone in order to achieve orally administer testosterone.

    Products: Testosteron EVER Pharma 1000 mg/4 ml Injektionslösung
  5. Drug

    Bemotrizinol

    go.drugbank.com/drugs/DB11206
    Approved

    Bemotrizinol, or bis-ethylhexyloxyphenol methoxyphenyl triazine, is an organic UV filter found in over-the-counter sunscreen products. It primarily absorbs UV-A rays.

  6. Drug

    Guaifenesin

    go.drugbank.com/drugs/DB00874
    ApprovedInvestigationalVet approved

    Since that time the agent has been a combination component of various prescription and non-prescription over-the-counter cough and cold products and is currently a widely available over-the-counter generic … there has also been contemporary research to suggest that guaifenesin possesses and is capable of demonstrating anticonvulsant and muscle relaxant effects to some degree possibly by acting as an NMDA receptor

    Mixtures: Viva Cold & Flu All In One Relief Caplets, Dover Coldonyl
  7. Drug

    Efgartigimod alfa

    go.drugbank.com/drugs/DB15270
    ApprovedInvestigational

    [L39496] IgG antibodies, including the autoantibodies responsible for MG symptoms, can be 'recycled', a process that significantly extends their half-life by evading lysosomal degradation via binding with … [A243759,A243784] Efgartigimod alfa is a first-in-class[L39501] antagonist of the neonatal Fc receptor (FcRn) used in the treatment of MG.

    Categories: Neonatal Fc Receptor Blocker
  8. Drug

    Lucanthone

    go.drugbank.com/drugs/DB04967
    Investigational

    One of the schistosomicides, it has been replaced largely by hycanthone and more recently praziquantel. (From Martindale The Extrapharmacopoeia, 30th ed., p46). It is currently being tested as a radiation sensitizer.

  9. Target

    Gamma-aminobutyric acid type B receptor subunit 1

    go.drugbank.com/bio_entities/BE0000217
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase ( … Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating

    Polypeptides: Gamma-aminobutyric acid type B receptor subunit 1Synonyms: GABA-B receptor 1
  10. Target

    Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

    go.drugbank.com/bio_entities/BE0000628
    TargetHumans

    Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells

    Polypeptides: Granulocyte-macrophage colony-stimulating factor receptor subunit alpha