Gamma-aminobutyric acid type B receptor subunit 1

BE0000217ProteinHumansGABBR1

Component of a heterodimeric G protein-coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054, PubMed:36103875, PubMed:9872316, PubMed:9872744). It is acted on by 15 drugs in DrugBank.

Gene name
GABBR1
UniProtKB entry
Q9UBS5Swiss-Prot
Cellular location
Cell membrane
Residues / weight
961 residues · 108,319 Da
Also known as
GABA-B receptor 1 · GABA-B-R1 · GABA-BR1 · GABABR1 · Gb1

Resolves to

Protein
UniProtQ9UBS5UniProt nameGABR1_HUMAN
Gene
HGNCHGNC:4070NCBI Gene2550GenBank3892594GeneCardsGABBR1
Pharmacology
IUPHAR/GtoPdb240KEGGhsa:2550
Structure
PDB4MQEPDB4MQFPDB4MR7
Drugs

What you can answer from here — as of September 07, 2019

15DrugsApproved to experimental, with action, bond type and pharmacological action
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10GO termsFunction, process and component, as structured annotations
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3Pfam domainsDomain architecture mapped to Pfam families and clans
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69+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Gamma-aminobutyric acid type B receptor subunit 1, how selective are they, and which programs against it are still in active trials?

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