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Displaying results 121 - 130 of 134165 in total

Pathway
Pegaptanib Action Pathway
smpdb.ca/view/SMP0126889
Drug action
This treatment approach is especially effective for patients with conditions like wet AMD, where VEGF-A levels are elevated and contribute to disease progression. … This polynucleotide aptamer is designed to bind to VEGF, reducing both angiogenesis and vessel permeability, particularly for neovascular age-related macular degeneration cases.
Drugs: Calcium · Pegaptanib
Enzymes: Antithrombin-III
Pathway
Ramucirumab Action Pathway
smpdb.ca/view/SMP0126890
Drug action
It is a human monoclonal antibody (IgG1) designed against VEGFR2, a transmembrane tyrosine kinase receptor expressed on endothelial cells. … , and migration of endothelial cells.
Drugs: Calcium · Ramucirumab
Enzymes: Antithrombin-III
Pathway
Pazopanib Action Pathway
smpdb.ca/view/SMP0126899
Drug action
, inhibited growth, and hypoxia in cancer cells. … for patients with advanced renal cell cancer and advanced soft tissue sarcoma.
Drugs: Calcium · Pazopanib
Enzymes: Antithrombin-III
Pathway
Lenvatinib Action Pathway
smpdb.ca/view/SMP0126908
Drug action
roles in processes like angiogenesis, tumor growth, and cancer progression. … Lenvatinib also inhibits other RTKs, such as fibroblast growth factor receptors (FGFR1, 2, 3, and 4), the platelet-derived growth factor receptor alpha (PDGFRα), KIT, and RET, all of which play crucial
Drugs: Calcium · Lenvatinib
Enzymes: Antithrombin-III
Pathway
Ripretinib Action Pathway
smpdb.ca/view/SMP0126912
Drug action
Ripretinib's mechanism of action involves inhibiting protein kinases, including both wild type and mutant forms of platelet-derived growth factor receptor A (PDGFRA) and KIT, which are implicated in the … This medication has been shown to inhibit other genes like PDGFRB, BRAF, VEGF, and TIE2 in laboratory studies.
Drugs: Calcium · Ripretinib
Enzymes: Antithrombin-III
Pathway
Faricimab Action Pathway
smpdb.ca/view/SMP0126914
Drug action
While existing treatments like aflibercept and ranibizumab focus solely on inhibiting VEGF-A, faricimab's unique mechanism involves binding to and depleting both VEGF-A and Ang-2. … endothelial growth factor A (VEGF-A) and angiopoietin-2 (Ang-2).
Drugs: Calcium · Faricimab
Enzymes: Antithrombin-III
Pathway
Heparin Action Pathway
smpdb.ca/view/SMP0123108
Drug action
It acts by binding antithrombin III that goes on to inactivate factor Xa. … It accelerates the neutralization of coagulation factors by antithrombin, inhibiting further clotting from occurring as well as any progression of current clots from forming.
Drugs: Heparin · Calcium
Enzymes: Antithrombin-III
Pathway
Certoparin Action Pathway
smpdb.ca/view/SMP0126157
Drug action
Certoparin can interact with herbs and supplements, it is best to avoid those with anticoagulant and antiplatelet activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba. … Certoparin is a heparin with a low molecular weight (LMWH), it prevents and treats venous thromboembolism.
Drugs: Calcium · Certoparin
Enzymes: Antithrombin-III
Pathway
Enoxaparin Action Pathway
smpdb.ca/view/SMP0126159
Drug action
It has an immediate onset of action, it binds to antithrombin III, inhibiting factor Xa ceasing the conversion of prothrombin to thrombin. … Enoxaparin can interact with some herbs and supplements, avoid those with anticoagulant and antiplatelet activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.
Drugs: Ardeparin · Calcium
Enzymes: Antithrombin-III
Pathway
Dalteparin Action Pathway
smpdb.ca/view/SMP0126160
Drug action
It binds to antithrombin III, inhibiting the formation of Xa and thrombin. … Dalteparin can interact with herbs and supplements, avoid those with anticoagulant and antiplatelet activity such as garlic, ginger, bilberry, danshen, piracetam and ginkgo biloba.
Drugs: Calcium · Dalteparin
Enzymes: Antithrombin-III