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Displaying results 121 - 130 of 10000 in total
  1. Drug

    Botaretigene sparoparvovec

    go.drugbank.com/drugs/DB16814
    Investigational

    Synonyms: DNA (RECOMBINANT PSEUDOTYPED ADENO-ASSOCIATED VIRUS 5 VECTOR AAV-RPGR HUMAN RHODOPSIN KINASE PROMOTER FRAGMENT-REGULATED HUMAN RETINITIS PIGMENTOSA GTPASE REGULATOR RPGR-ORF15 ISOFORM GENE VARIANT PLUS, ADENO-ASSOCIATED VIRUS 2 INVERTED TERMINAL REPEAT FL
  2. Drug

    NTLA-2002

    go.drugbank.com/drugs/DB17597
    Investigational

    NTLA-2002 is a lipid nanoparticle encapsulating single guide RNA (G012267) targeting the human KLKB1 gene and messenger RNA (mRNA000042) encoding Cas9. … It is an investigational therapy designed to knock out the target gene kallikrein B1 (KLKB1) to reduce plasma kallikrein activity, thereby preventing hereditary angioedema attacks.[L45738]

    Synonyms: lipid nanoparticle encapsulating single guide RNA (G012267) targeting the human KLKB1 gene and messenger RNA (mRNA000042) encoding Cas9
  3. Drug

    Valziflocept

    go.drugbank.com/drugs/DB17728
    Investigational

    Synonyms: Human immunoglobulin gamma fc region receptor ii-b (fc.gamma.rii-b), extracellular n-terminal fragment, produced in escherichia coli, Recombinant human soluble fc-gamma receptor iib
  4. Drug

    4A10

    go.drugbank.com/drugs/DB18292
    Experimental

    Synonyms: Anti-interleukin-7 Receptor α Monoclonal antibody
  5. Drug

    Prolactin G129R

    go.drugbank.com/drugs/DB18431
    Investigational

    Synonyms: Prolactin receptor antagonist (Prolactin G129R)
  6. Drug

    Sipavibart

    go.drugbank.com/drugs/DB21908
    ApprovedInvestigational

    [A274098] It works by binding to the SARS-CoV-2 spike protein receptor binding domain (RBD), neutralize the virus and preventing its entry into the host cell. … Sipavibart is a recombinant human IgG1 monoclonal antibody that is long-acting.

    Synonyms: Immunoglobulin G1-lambda, anti-[Homo sapiens severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], Homo sapiens monoclonal antibody, Immunoglobulin G1 [242-phenylalanine,243-glutamic acid,260-tyrosine,262-threonine,264-glutamic acid,339-serine], anti-(severe acute respiratory syndrome coronavirus 2 spike glycoprotein receptor-binding
  7. Drug

    CLL1-CD33 compound chimeric antigen receptor T cells

    go.drugbank.com/drugs/DB18568
    Investigational

    Synonyms: CLL1-CD33 compound chimeric antigen receptor T cells, Chimeric Antigen Receptor immunotherapy directed against CLL-1 and CD33
  8. Drug

    B7-H3-specific chimeric antigen receptor T cells

    go.drugbank.com/drugs/DB18567
    Experimental

    Synonyms: B7-H3-specific chimeric antigen receptor T cells, Autologous chimeric antigen receptor (CAR) T cells targeting B7-H3
  9. Drug

    PA3-17

    go.drugbank.com/drugs/DB18569
    Investigational

    PA3-17 is CD7-directed chimeric antigen receptor (CAR) T-cell therapy.

    Synonyms: Chimeric Antigen Receptor T Cells targeting CD7
  10. Drug

    Veligrotug

    go.drugbank.com/drugs/DB18976
    Approved

    Veligrotug is a humanized IgG1 monoclonal antibody that binds the insulin-like growth factor-1 receptor and blocks ligand-induced receptor autophosphorylation, interrupting IGF-1R signaling. … [L63798] Although its precise mechanism in thyroid eye disease has not been fully characterized, IGF-1R blockade reduces the proptosis and diplopia that define the condition.

    Categories: Insulin-like Growth Factor-1 Receptor InhibitorSynonyms: Immunoglobulin G1-kappa, anti-[Homo sapiens IGF1R (insulin-like growth factor 1 receptor, IGF1-R, IGF-1R, CD221)], chimeric monoclonal antibody (gamma1 heavy chain chimeric (1-454) [VH (Mus musculus IGHV1S81, Immunoglobulin G1, anti-(human insulin-like growth factor I receptor) (human-Mus musculus monoclonal VRDN-001 γ1-chain), disulfide with human-Mus musculus monoclonal VRDN-001 κ-chain, dimer