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Azacitidine
go.drugbank.com/drugs/DB00928ApprovedInvestigationalOne of them is the induction of cytotoxicity. As an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and inhibiting protein and DNA synthesis. … [A1415] The use of oral azacitidine for the treatment of AML in patients in complete remission was approved by the FDA in September 2020.[L35335]
Categories: Antineoplastic and Immunomodulating Agents, Nucleic Acids, Nucleotides, and NucleosidesProducts: Vidaza powder for suspension for injection 100mg/vial, AZADINE POWDER FOR SUSPENSION FOR INJECTION 100MG/VIALHuman C1-esterase inhibitor
go.drugbank.com/drugs/DB06404ApprovedInvestigationalThe disease is characterized by acute attacks of painful, and in some cases, fatal swelling of several soft tissues or edema, which may last up to five days when untreated.[L16586, L16606] … [L16586, L16606] This drug is indicated for prophylaxis and treatment of Hereditary Angioedema (HAE), a human genetic disorder caused by a shortage of C1 inhibitor activity that results in an overreaction
Categories: Drugs Used in Hereditary Angioedema, Blood and Blood Forming OrgansSynonyms: C1-INHArsenic trioxide
go.drugbank.com/drugs/DB01169ApprovedInvestigationalIn general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of dangerous adverse effects. … It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis.
Categories: Antineoplastic and Immunomodulating AgentsProducts: ASADIN INJECTION 1.0MG/ML, LEUSENOX 10 MG/10 ML IV INFÜZYON IÇIN KONSANTRE ÇÖZELTI IÇEREN AMPUL, 1 ADETDabigatran etexilate
go.drugbank.com/drugs/DB06695ApprovedInvestigationalDabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin inhibitor [dabigatran]. … [A177463] In contrast to warfarin, because its anticoagulant effects are predictable, lab monitoring is not necessary.[A177463] Dabigatran etexilate was approved by the FDA in 2010.[L6022]
Categories: Blood and Blood Forming OrgansProducts: Pradaxa 150mg, Hard Capsules, Dabigatran Sandoz Capsule 150mgDiethylcarbamazine
go.drugbank.com/drugs/DB00711ApprovedInvestigationalVet approvedWithdrawnAn anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.
Categories: Piperazine and Derivatives, Antiparasitic Products, Insecticides and RepellentsProducts: Hetrazan Tab 50mgIdecabtagene vicleucel
go.drugbank.com/drugs/DB16665ApprovedInvestigational[L32858] Idecabtagene vicleucel was approved by the FDA on March 26, 2021 [L32863] and by the EMA on August 18, 2021.[L51003] … [A232563] Multiple myeloma is typically treated with an immunomodulatory agent like [lenalidomide],[A232593] a proteasome inhibitor like [bortezomib], or an anti-CD38 monoclonal antibody like [isatuximab
Synonyms: Anti-BCMA CAR T cellCategories: Amino Acids, Peptides, and Proteins, Antineoplastic cell and gene therapyDolichovespula maculata venom protein
go.drugbank.com/drugs/DB10958ApprovedDolichovespula maculata venom protein is an extract of Dolichovespula maculata venom. Dolichovespula maculata venom protein is used in allergenic testing.
Mixtures: Venomil Inj Mixed 300mcg/dose, Mixed Vespid Venom Protein InjCategories: Bee and Wasp VenomTrovafloxacin
go.drugbank.com/drugs/DB00685ApprovedWithdrawnIt exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. … Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer.
Categories: Topoisomerase II InhibitorsProducts: Trovan Tablets 100mg, Trovan Tablets 200mgTibolone
go.drugbank.com/drugs/DB09070ApprovedInvestigationalTibolone (Livial, Org OD 14), produced by Organon (West Orange, NJ), is a synthetic steroid that possesses estrogenic, androgenic and progestogenic properties. … Tibolone is a synthetic steroid hormone drug, which is mainly non-selective in its binding profile, acting as an agonist primarily at estrogen receptors (ER), with a preference for ER alpha [L1874].
Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital SystemSynonyms: 17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-oneCapmatinib
go.drugbank.com/drugs/DB11791ApprovedInvestigational[L13347] The presence of the mutation must be confirmed by an FDA-approved test, such as the FoundationOne CDx assay (manufactured by Foundation Medicine, Inc.), which was approved by the FDA on the same … Manufactured by Novartis and marketed under the brand name Tabrecta, capmatinib was granted accelerated approval by the FDA on May 6, 2020,[L13380] for the treatment of NSCLC in patients whose tumors have
Categories: Antineoplastic and Immunomodulating Agents, MATE 2-K InhibitorsProducts: TABRECTA FILM-COATED TABLET 150mg, Rahika 150mg Film-coated Tablet