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Pralatrexate
go.drugbank.com/drugs/DB06813ApprovedInvestigational[A246703] As such, pralatrexate is thought to have a better therapeutic window compared to other antifolate analogs due to the novel target of RFC. … Pralatrexate was developed in response due to the inferior responses of patients using the standard therapy for their B-cells counterparts.
Synonyms: 10-Propargyl-10-deazaaminopterinProducts: DIFOLTA 20 MG/ML SOLUCION PARA INFUSION, SOLUTION FOR INFUSION 20MG/MLAlogliptin
go.drugbank.com/drugs/DB06203ApprovedInvestigationalChemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. … Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4).
Mixtures: OSENI 25 MG/15 MG TABLETS, OSENI 25 MG/15 MG TABLETSCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesFenspiride
go.drugbank.com/drugs/DB08979InvestigationalFenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. … well as for maintenance treatment of asthma.
Products: OXOFEN 2 MG/ML ŞURUP ,150 ML, PASFEN 2MG/ML ŞURUPEnzalutamide
go.drugbank.com/drugs/DB08899ApprovedInvestigationalCompared to the average time of 10 to 15 years for a drug to go from pre-clinical to clinical studies, enzalutamide was developed relatively rapidly.[A252667] … [A252667,A252642] Due to a favorable pharmacological profile, a phase 1 study of enzalutamide was initiated in July 2007.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InhibitorsProducts: XTANDI 40 MG, XTANDI ® 40 MGDornase alfa
go.drugbank.com/drugs/DB00003ApprovedInvestigationalDornase alfa is a biosynthetic form of human deoxyribunuclease I (DNase I) enzyme. It is produced in genetically modified Chinese hamster ovary (CHO) cells using recombinant DNA technology. … In individuals with cystic fibrosis, extracellular DNA, which is an extremely viscous anion, is released by degenerating leukocytes that accumulate during inflammatory responses to infections.
Products: PULMOZYME 2.5 MG/2.5 ML İNHALASYON ÇÖZELTİSİ, 30 ADET, PULMOZYMESOLUCION PARA INHALACION 1MG/MLAluminum zirconium tetrachlorohydrex gly
go.drugbank.com/drugs/DB11149ApprovedWithdrawnAluminum zirconium tetrachlorohydrex gly is a common active ingredient in personal care products as an antiperspirant agent.
Products: Mitchum M3 Invisible Solid, Ban U. Fr. & Dry Wo Ap Roll-ON W Aloe-skiingMagnesium cation
go.drugbank.com/drugs/DB01378ApprovedInvestigationalNutraceuticalWithdrawnMagnesium hydroxide is used primarily in "Milk of Magnesia", a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. … When taken internally by mouth as a laxative, the osmotic force of the magnesia suspension acts to draw fluids from the body and to retain those already within the lumen of the intestine, serving to distend
Mixtures: KALSİMAG-D3 1000 MG/300 MG/880 IU EFERVESAN GRANÜL, 30 ADET, KALSİMAG-D3 1000 MG/300 MG/880 IU EFERVESAN GRANÜL, 40 ADETSynonyms: Magnesium, ion(Mg2+)Etidronic acid
go.drugbank.com/drugs/DB01077ApprovedInvestigationalEtidronic acid is a first generation bisphosphonate similar to [clodronic acid] and [tiludronic acid]. … [A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.
Products: DIDRONAT 200 MG TABLET, 60 ADET, DIDRONAT 400 MG TABLET, 30 ADETInterferon beta-1a
go.drugbank.com/drugs/DB00060ApprovedInvestigationalHuman interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSynonyms: Interferon beta 1-aSelexipag
go.drugbank.com/drugs/DB11362ApprovedInvestigationalPAH is a relatively rare disease with usually a poor prognosis requiring more treatment options to prolong long-term outcomes. … Marketed by Actelion Pharmaceuticals under brand name Uptravi, selexipag and its active metabolite, ACT-333679 (MRE-269), act as agonists of the prostacyclin receptor to increase vasodilation in the pulmonary
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: UPTRAVI 200 MCG FILM KAPLI TABLET, 140 ADET, SELPENZA 200 MCG FİLM KAPLI TABLET, 140 ADET