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Diazepam
go.drugbank.com/drugs/DB00829ApprovedIllicitInvestigationalVet approvedformulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 [L5200]. … It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal
Products: E Pam Tab 5mg, E Pam Tab 2mgRemoxipride
go.drugbank.com/drugs/DB00409ApprovedWithdrawn[A215422] It gained approval in the UK in 1989 but was withdrawn in 1993 after it was found to be associated with an increased incidence of aplastic anemia.[A215422,A215512]
Dexmethylphenidate
go.drugbank.com/drugs/DB06701ApprovedInvestigationalThe d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture[A177181]. … Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002[A177181]. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193].
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeClidinium
go.drugbank.com/drugs/DB00771ApprovedIt is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome. … Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.
Synonyms: Bromuro de clidinio, Bromure de ClidiniumSiponimod
go.drugbank.com/drugs/DB12371ApprovedInvestigationalMost patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years of life. … Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system that is chronic and inflammatory, disrupting communication between the brain and other parts of the body.
Sildenafil
go.drugbank.com/drugs/DB00203ApprovedInvestigationaland the increased flow of blood into the spongy erectile tissue of the penis that consequently allows it to grow in size and become erect and rigid [F3850, F3853, F3856, F3859, F3883, F3886, L5611, L5614 … The result of doing so allows cGMP present in both the penis and pulmonary vasculature to elicit smooth muscle relaxation and vasodilation that subsequently facilitates relief in pulmonary arterial hypertension
Epoprostenol
go.drugbank.com/drugs/DB01240ApprovedInvestigationalThe sodium salt has been also used to treat primary pulmonary hypertension.
Products: Estenol 0,5 mg İnfüzyonluk Çözelti Hazırlamak İçin Toz ve Çözücü, 1 ADET, Estenol 1,5 mg İnfüzyonluk Çözelti Hazırlamak İçin Toz ve Çözücü, 1 ADETCemiplimab
go.drugbank.com/drugs/DB14707ApprovedInvestigationalBy blocking PD-1, cemiplimab works to enhance T cell-mediated antitumour responses. … [L43867] The EMA then approved Libtayo (cemiplimab) for that indication later in the same year. [L43872]
Cenegermin
go.drugbank.com/drugs/DB13926ApprovedInvestigationalThe prevalence of neurotrophic keratitis has been estimated to be less than five in 10,000 individuals. … The loss of corneal sensation impairs corneal health, causing progressive damage to the top layer of the cornea, including corneal thinning, ulceration, and perforation in severe cases.
Vutrisiran
go.drugbank.com/drugs/DB16699ApprovedInvestigational[A249010] TTR mutations lead to the formation of misfolded TTR proteins, which form amyloid fibrils that deposit in different types of tissues. … [A249010] The Val30Met variant is the most prevalent among hereditary ATTR patients with polyneuropathy, especially in Portugal, France, Sweden, and Japan.