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Displaying results 1371 - 1380 of 10000 in total

Drug
Levothyroxine
go.drugbank.com/drugs/DB00451
ApprovedInvestigational
to the serum TSH. … While T4 is the major product secreted by the thyroid gland, T3 exerts the majority of the physiological effects of the thyroid hormones; T4 and T3 have a relative
Synonyms: T4, L-T4Categories: Agents used to treat hypothyroidism
Drug
Perindopril
go.drugbank.com/drugs/DB00790
ApprovedInvestigational
Perindopril may be used to treat mild to moderate essential hypertension, mild to moderate congestive heart failure, and to reduce the cardiovascular risk of individuals with hypertension or post-myocardial … Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII).
Mixtures: PERINDO/IN RAT T 5/1.25, PERINDO/IN RAT T 5/1.25Categories: Agents Acting on the Renin-Angiotensin System
Drug
Apalutamide
go.drugbank.com/drugs/DB11901
ApprovedInvestigational
Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements [A31846] … In a phase-2 multicenter open-label study, 89% of patients with non-metastatic, castration-resistant prostate cancer had ≥50% PSA decline at week 12 of apalutamide treatment [A31846].
Categories: Androgen Receptor Inhibitors
Drug
Sulfadimethoxine
go.drugbank.com/drugs/DB06150
ApprovedVet approvedWithdrawn
In the US, sulfadimethoxine is one of the products that have been withdrawn or removed from the market after being found to be unsafe or not effective.[L43942] … It is widely available in Russia as an over-the-counter drug manufactured by a number of Russian pharmaceutical companies.
Mixtures: TP-SULTRIME 80/400MG/G POWDER, TP-SULTRIXIN 40/200MG/ML SOLUTION
Drug
Myrcludex B
go.drugbank.com/drugs/DB14853
Investigational
Myrcludex B is under investigation in clinical trial NCT03546621 (A Multicenter, Open-label, Randomized Clinical Study to Assess Efficacy and Safety of 3 Doses of Myrcludex B for 24 Weeks in Combination … With Tenofovir Compared to Tenofovir Alone to Suppress HBV Replication in Patients With Chronic Hepatitis D).
Drug
Inaxaplin
go.drugbank.com/drugs/DB21521
Investigational
Inaxaplin is under investigation in clinical trial NCT06794996 (Phase 2b Open-label Study of Inaxaplin in Participants With Proteinuric APOL1 Mediated Kidney Disease).
Drug
Bismuth subgallate
go.drugbank.com/drugs/DB13909
Approved
internal deodorant where it is often employed as the primary active ingredient. … Possessing protective effects on the gastric mucosa, strong astringent effects, and not as yet elucidated antimicrobial and hemostatic actions, bismuth subgallate is most commonly available as an over-the-counter
Drug
Dabigatran etexilate
go.drugbank.com/drugs/DB06695
ApprovedInvestigational
[A177463, A6970, L34675, L34680] Dabigatran etexilate may be used to decrease the risk of venous thromboembolic events in patients in whom anticoagulation therapy is indicated. … Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin inhibitor [dabigatran].
Drug
Arginine
go.drugbank.com/drugs/DB00125
ApprovedInvestigationalNutraceutical
An essential amino acid that is physiologically active in the L-form.
Mixtures: Clinimix E, Clinimix E
Drug
Fondaparinux
go.drugbank.com/drugs/DB00569
ApprovedInvestigational
The monomeric sequence in heparin and HS is thought to form the high affinity binding site for the natural anti-coagulant factor, antithrombin III (ATIII). … Fondaparinux may be used: to prevent venous thromboembolism in patients who have undergone orthopedic surgery of the lower limbs (e.g. hip fracture, hip replacement and knee surgery); to prevent VTE in