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Displaying results 131 - 140 of 134146 in total
  1. Pathway

    Pantoprazole Action Pathway

    smpdb.ca/view/SMP0123293
    Drug action

    The bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions. … In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+.

    Drugs: Pantoprazole · Potassium cation · Zinc
    Enzymes: Chloride anion exchanger
  2. Pathway

    Kidney Function - Ascending Limb of The Loop of Henle

    smpdb.ca/view/SMP0121010
    Physiological

    Chloride, potassium, and sodium are co-transported across the apical membrane (closest to the lumen) via transporters from the filtrate. … In addition, the three ions are transported across the basolateral membrane (closest to the renal interstitium) via other means such as the sodium potassium ATPase transports and the chloride channels

    Drugs: Potassium cation · Urea
    Enzymes: Chloride channel protein ClC-Ka
  3. Pathway

    Furosemide Diuretic Action Pathway

    smpdb.ca/view/SMP0122712
    Drug action

    This is relieves symptoms such as swelling/ edema and hypertension in patients. Furosemide may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … It binds to this transporter, inhibiting it and preventing Na+, K+ and Cl- reabsorption from the lumen.

    Drugs: Furosemide · Potassium cation
    Enzymes: Chloride channel protein ClC-Ka
  4. Pathway

    Methyclothiazide Action Pathway

    smpdb.ca/view/SMP0000081
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Methyclothiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  5. Pathway

    Hydroflumethiazide Action Pathway

    smpdb.ca/view/SMP0000108
    Drug action

    Solute carrier family 12 member 3 transports chloride and sodium from lumen to epithelial cell, and sodium/potassium ATPases facilitate the export of sodium to basolateral interstitium to provide sodium … It can inhibit the solute carrier family 12 member 3 (also known as sodium-chloride symporter) in the nephron to prevent water reabsorption.

    Drugs: Cysteine · Hydroflumethiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  6. Pathway

    Furosemide Action Pathway

    smpdb.ca/view/SMP0000115
    Drug action

    Furosemide can bind and inhibit sodium-potassium-chloride cotransporter (NKCC2/SLC22A1) to prevent the water reabsorption in nephron. … Inhibition of sodium-potassium-chloride cotransporter can prevent transportation of sodium from lumen to basolateral interstitium, which lead to more hypertonic in lumen and less hypertonic in basolateral

    Drugs: Cysteine · Furosemide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  7. Pathway

    Trichlormethiazide Action Pathway

    smpdb.ca/view/SMP0000121
    Drug action

    Trichloromethiazide acts by inhibiting chloride and potentially sodium reabsorption in the ascending loop of Henle, specifically at solute carrier family 12 member 3. … Thiazides and thiazide-like drugs are diuretics commonly employed to control hypertension.

    Drugs: Cysteine · Trichlormethiazide · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  8. Pathway

    Eplerenone Action Pathway (Old)

    smpdb.ca/view/SMP0000135
    Drug action

    Aldosterone increases sodium reabsorption and potassium excretion by up-regulating the expression of basolateral sodium-potassium ATPases as well as luminal (apical) sodium and potassium channels. … This causes the interstitium to become hyperosmotic and establishes an osmotic gradient, facilitating water reabsorption through aquaporin channels.

    Drugs: Cysteine · Eplerenone · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  9. Pathway

    Kidney Function

    smpdb.ca/view/SMP0000483
    Physiological

    Blood pressure is regulated by the hormones angiotensin II and aldosterone, which increases sodium chloride reabsorption. … Sodium and chlorine are also reabsorbed in the early distal convoluted tubule. Finally, sodium and water are reabsorbed in the collecting tubules.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka
  10. Pathway

    Cystinuria

    smpdb.ca/view/SMP0000723
    Disease

    The mutations cause this process to be compromised and allows the amino acids to build up and have a high concentration in urine. This causes crystals to form and become stones as they grow larger. … These stones can become lodged in the bladder or in the kidneys which can cause pain, develop infection and disrupt the passing of urine through the urinary tract if the stones create a blockage there.

    Drugs: Cysteine · Potassium cation · Urea
    Enzymes: Sodium- and chloride-dependent transporter XTRP3, Chloride channel protein ClC-Ka