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Nedisertib
go.drugbank.com/drugs/DB16252InvestigationalNedisertib is under investigation in clinical trial NCT03770689 (Study of M3814 in Combination With Capecitabine and Radiotherapy in Rectal Cancer).
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingNirsevimab
go.drugbank.com/drugs/DB16258ApprovedInvestigational[L44146] It binds to the prefusion conformation of the RSV F protein, a glycoprotein involved in the membrane fusion step of the viral entry process, and neutralizes several RSV A and B strains. … [A254691] This is due to a modification in the Fc region of nirsevimab that grants it a longer half-time compared to typical monoclonal antibodies.
Categories: Respiratory Syncytial Virus Anti-F Protein Monoclonal AntibodySynonyms: Immunoglobulin g1-kappa, anti-(human respiratory syncytial virus fusion glycoprotein f0 (protein f))human monoclonal antibody.gamma.1 heavy chain (1-456) (human vh (homo sapiens ighv1-69*01(ighd)-ighj4, *01 (90.1%)) (8.8.19) (1-126) -homo sapiens ighg1*03Parathyroid Hormone-Related Protein 1-36
go.drugbank.com/drugs/DB16278InvestigationalParathyroid Hormone-Related Protein 1-36 is under investigation in clinical trial NCT00853723 (Comparison Study of Pthrp and PTH to Treat Osteoporosis).
Synonyms: 1-36 hpthrp, 1-36 human humoral hypercalcemic factorPegcrisantaspase
go.drugbank.com/drugs/DB16281InvestigationalPegcrisantaspase is under investigation in clinical trial NCT02257684 (A Dose Confirmation and Pharmacokinetic Study of Pegcrisantaspase Administered as Intravenous (IV) Infusion in Children and Young
Synonyms: mPEG-R-Crisantaspase, Pegylated dickeya chrysanthemi l-asparaginasePelacarsen
go.drugbank.com/drugs/DB16284InvestigationalPelacarsen is under investigation in clinical trial NCT03070782 (Phase 2 Study of ISIS 681257 (Akcea-apo(a)-lrx) in Participants With Hyperlipoproteinemia(a) and Cardiovascular Disease).
Synonyms: AKCEA-APO(a)-LRx, IONIS-APO(a)-LRxPemlimogene merolisbac
go.drugbank.com/drugs/DB16286InvestigationalPemlimogene merolisbac is under investigation in clinical trial NCT03371381 (An Efficacy and Safety Study of JNJ-64041757, a Live Attenuated Listeria Monocytogenes Immunotherapy, in Combination With Nivolumab
Synonyms: (actan100), 5 tandem copies of a 21 amino acid fr, Recombinant live-attenuated double-deleted (ladd) strain of listeria monocytogenes (lm .delta.acta/.delta.inlb) expressing a fusion protein comprising the n-terminal 100 amino acids of the lm acta proteinB27PD
go.drugbank.com/drugs/DB16289InvestigationalB27PD is under investigation in clinical trial NCT01195948 (Optiquel® as Corticosteroid-sparing Therapy for Chronic Noninfectious Uveitis).
Poseltinib
go.drugbank.com/drugs/DB16299InvestigationalPoseltinib is under investigation in clinical trial NCT02628028 (A Study of LY3337641 in Rheumatoid Arthritis).
Categories: Heterocyclic Compounds, 1-RingRevusiran
go.drugbank.com/drugs/DB16309InvestigationalRevusiran is under investigation in clinical trial NCT02319005 (ENDEAVOUR: Phase 3 Multicenter Study of Revusiran (ALN-TTRSC) in Patients With Transthyretin (TTR) Mediated Familial Amyloidotic Cardiomyopathy
Ribaxamase
go.drugbank.com/drugs/DB16311InvestigationalRibaxamase is under investigation in clinical trial NCT02563106 (A Study of SYN-004 for the Prevention of c.diff in Patients With a LRTI).