Nedisertib

DB16252InvestigationalSmall molecule

Nedisertib is under investigation in clinical trial NCT03770689 (Study of M3814 in Combination With Capecitabine and Radiotherapy in Rectal Cancer).

Chemical structure of Nedisertib
Formula / weight
C24H21ClFN5O3 · 481.91 g/mol (avg)
Also known as
Peposertib
Code names
M-3814 · MSC-2490484A

Resolves to

Compound
UNIIGN429E725ACAS1637542-33-6ChEMBLCHEMBL4297629
Structure
InChIKeyMOWXJLUYGFNTAL-DEOSSOPVSA-NSMILESCOC1=NN=C(C=C1)[C@@H](O)C1=C(Cl)C=C(F)C(=C1)C1=NC=NC2=C1C=CC(=C2)N1CCOCC1
Targets
P78527PRKDC

What you can answer from here — as of August 30, 2025

1Protein targetEach mapped to UniProt, with action and pharmacological action
Listed above
18Clinical trialsPhase, status and sponsor resolved per trial
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1+ReferenceStructured and connected to the statements they support
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Which drugs share a target with Nedisertib, and which of those have an active Phase 3 trial?

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