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Indapamide
go.drugbank.com/drugs/DB00808ApprovedInvestigational[A204134,A204161] Indapamide is characterized by both a methylindoline and a sulfamoyl chlorobenzamide functional group, with the former being largely responsible for the molecule’s lipid solubility … The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension.
Mixtures: NORMOTRİ FORT 5 MG/2.5 MG/8.14 MG FİLM KAPLI TABLET, 30 ADET, NORMOTRİ FORT 10 MG/2.5 MG/8.14 MG FİLM KAPLI TABLET, 30 ADETCategories: Antihypertensive Agents Indicated for HypertensionVanzacaftor
go.drugbank.com/drugs/DB18373ApprovedInvestigational], a CFTR potentiator, for the treatment of patients with responsive CFTR mutations. … [L52275,A179677] Vanzacaftor was first approved by the US FDA in December 2024 in combination with another CFTR corrector - [tezacaftor], which binds to a different site than vanzacaftor - and [deutivacaftor
Etoricoxib
go.drugbank.com/drugs/DB01628ApprovedInvestigationalWithdrawnIt is approved in more than 60 countries worldwide but not in the US. … Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2) to reduce the generation of prostaglandins (PGs) from arachidonic acid.
Piperonyl butoxide
go.drugbank.com/drugs/DB09350ApprovedVet approvedIt is used for the treatment of head, pubic (crab), and body lice. Piperonyl butoxide is a synergist. … It has no pesticidal activity of its own, but acts to increase the activity of pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone.
Mixtures: Para Special Shampoo for Lice & Nits, Up and up lice killing maximum strengthCategories: Compounds used in a research, industrial, or household settingAminobenzoic acid
go.drugbank.com/drugs/DB02362ApprovedWithdrawnThe potassium salt is used therapeutically in fibrotic skin disorders.
Categories: Protectives Against UV-Radiation for Topical Use, Protectives Against UV-RadiationSomapacitan
go.drugbank.com/drugs/DB15093ApprovedInvestigational[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily.
Sparfloxacin
go.drugbank.com/drugs/DB01208ApprovedWithdrawnSparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseVaborbactam
go.drugbank.com/drugs/DB12107ApprovedInvestigationalVabomere consists of vaborbactam and [Meropenem] for intravenous administration. … In August 2017, a combination antibacterial therapy under the market name Vabomere was approved by the FDA for the treatment of adult patients with complicated urinary tract infections (cUTI).
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseMaralixibat
go.drugbank.com/drugs/DB16226ApprovedInvestigational[L44396] On July 21, 2023, maralixibat was also approved by Health Canada.[L47541] … [L38834] In October 2022, the EMA's Committee for Medicinal Products for Human Use (CHMP) recommended maralixibat be granted marketing authorization for the treatment of cholestatic pruritus in patients
Ethchlorvynol
go.drugbank.com/drugs/DB00189ApprovedIllicitWithdrawnIt has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists.