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Displaying results 1421 - 1430 of 1804 in total
  1. Drug

    Buspirone

    go.drugbank.com/drugs/DB00490
    ApprovedInvestigational

    [L7375] The potential use of buspirone in combination with [melatonin] in depression and cognitive impairment via promoting neurogenesis has also been investigated.[A181751] … Belonging to the azaspirodecanedione drug class,[A180991] buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates

    Categories: Dopamine D2 Receptor Antagonists
  2. Drug

    Lasofoxifene

    go.drugbank.com/drugs/DB06202
    ApprovedInvestigationalWithdrawn

    Lasofoxifene is a non-steroidal 3rd generation selective estrogen receptor modulator (SERM) that selectively binds to both ERα and ERβ with high affinity.

    Categories: Selective Estrogen Receptor Modulators
  3. Drug

    Floxuridine

    go.drugbank.com/drugs/DB00322
    ApprovedInvestigational

    An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous,...

  4. Drug

    Metoclopramide

    go.drugbank.com/drugs/DB01233
    ApprovedInvestigational

    Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat...

    Categories: Dopamine D2 Receptor Antagonists
  5. Drug

    Givosiran

    go.drugbank.com/drugs/DB15066
    Approved

    Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United ...

  6. Drug

    Tobramycin

    go.drugbank.com/drugs/DB00684
    ApprovedInvestigational

    Aminoglycosides, many of which are derived directly from Streptomyces spp., are concentration-dependent bactericidal antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative organisms. Inhaled tobramycin is n...

  7. Target

    Kainate receptors

    go.drugbank.com/bio_entities/BE0009793
    TargetHumans

    The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist … Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid.

    Polypeptides: Glutamate receptor ionotropic, kainate 1, Glutamate receptor ionotropic, kainate 2Synonyms: Glutamate receptor 5, Glutamate receptor 6
  8. Drug

    alpha-Tocopherol succinate

    go.drugbank.com/drugs/DB14001
    ApprovedNutraceuticalVet approved

    Alpha-tocopherol is the primary form of vitamin E that is preferentially used by the human body to meet appropriate dietary requirements. In particular, the RRR-alpha-tocopherol (or sometimes called the d-alpha-tocopherol stereoisomer) s...

    Mixtures: Vita Day Tab
  9. Target

    Human Retinoid X Receptors (RXRs)

    go.drugbank.com/bio_entities/BE0010096
    TargetHumans

    Receptor for retinoic acid. … Receptor for retinoic acid.

    Polypeptides: Retinoic acid receptor RXR-alpha, Retinoic acid receptor RXR-betaSynonyms: Retinoid X receptor alpha, Retinoid X receptor beta
  10. Target

    Peroxisome proliferator-activated receptors

    go.drugbank.com/bio_entities/BE0010120
    TargetHumans and other mammals

    Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. … Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids.

    Polypeptides: Peroxisome proliferator-activated receptor alpha, Peroxisome proliferator-activated receptor deltaSynonyms: Nuclear hormone receptor 1, Nuclear receptor subfamily 1 group C member 1