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Sparteine
go.drugbank.com/drugs/DB06727ApprovedWithdrawnSparteine is not currently FDA-approved for human use, and its salt, sparteine sulfate, is one of the products that have been withdrawn or removed from the market for reasons of safety or effectiveness
Somapacitan
go.drugbank.com/drugs/DB15093ApprovedInvestigationalSomapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency. This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect ...
Lefamulin
go.drugbank.com/drugs/DB12825ApprovedLefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. … [L8093] This drug is the first semi-synthetic pleuromutilin that has been designed for systemic administration.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseLevonorgestrel
go.drugbank.com/drugs/DB00367ApprovedInvestigationalinitially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older
Categories: Hormonal Contraceptives for Systemic UseProducts: ONIVE 1® 1.5 MG TABLETA, ONIVE 2® 0.75 MG TABLETASNedosiran
go.drugbank.com/drugs/DB17635ApprovedInvestigationalNedosiran is an RNA interference targeting hepatic lactate dehydrogenase, the enzyme responsible for the conversion of glyoxylate to oxalate. … [A261685] Nedosiran was approved by the FDA on October 2<sup>nd</sup>, 2023, under the brand name RIVFLOZA to lower urinary oxalate levels in children 9 years of age and older and adults with primary
Mangafodipir
go.drugbank.com/drugs/DB06796ApprovedInvestigationalWithdrawnThis drug is made up of paramagnetic manganese (II) ions combined with the chelating agent _fodipir_ (dipyridoxyl diphosphate, DPDP). … Manganese absorption into the tissues that makes the normal tissue appear brighter in MRI is limited in abnormal or cancerous tissue.
Categories: Compounds used in a research, industrial, or household settingForeskin keratinocyte (neonatal)
go.drugbank.com/drugs/DB10772ApprovedIt is used for grafting onto partial-thickness wounds, where it offers a favorable matrix for host cell migration [L2452]. … Foreskin keratinocytes are a form of skin cells that are cultured as a skin cell replacement for wounds, to accelerate wound closure and healing [L2434], [L2460].
Odesivimab
go.drugbank.com/drugs/DB15900ApprovedInvestigational[A221825, A221830] A recent large-scale study elucidated that both neutralizing and Fc-mediated functions of antibodies were important for therapeutic benefit in animal models of EBOV infection. … Ebola virus (EBOV) remains an important human pathogen within the _Ebolavirus_ genus, having been responsible for at least 17 known outbreaks with an average case fatality rate of 43.92%.
Categories: Treatments for Ebola Virus DiseaseAmifostine
go.drugbank.com/drugs/DB01143ApprovedInvestigationalA phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Categories: Detoxifying Agents for Antineoplastic Treatment, Compounds used in a research, industrial, or household settingTyrothricin
go.drugbank.com/drugs/DB13503ApprovedWithdrawnNevertheless, as tyrothricin is both cytolytic and hemolytic, it does demonstrate systemic toxicity [L4019, L4021, L4022], although certain formulations that are safe for human use like throat lozenges
Categories: Antibiotics for Topical Use