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Displaying results 1461 - 1470 of 8696 in total
  1. Target

    Sigma receptor

    go.drugbank.com/bio_entities/BE0004897
    TargetHumans

    Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021) … Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity).

    Polypeptides: Sigma non-opioid intracellular receptor 1, Membrane-associated progesterone receptor component 1Synonyms: Sigma1-receptor, Sigma 1-type opioid receptor
  2. Target

    Estrogen receptor

    go.drugbank.com/bio_entities/BE0010245
    TargetHumans

    Nuclear hormone receptor. … Nuclear hormone receptor.

    Polypeptides: Estrogen receptor, Estrogen receptor betaSynonyms: Estradiol receptor, Nuclear receptor subfamily 3 group A member 1
  3. Target

    Somatostatin receptor

    go.drugbank.com/bio_entities/BE0010250
    TargetHumans

    Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. … It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade.

    Polypeptides: Somatostatin receptor type 1, Somatostatin receptor type 2Function: G protein-coupled receptor activity
  4. Target

    Cannabinoid receptor

    go.drugbank.com/bio_entities/BE0010258
    TargetHumans

    Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. … May function in inflammatory response, nociceptive transmission and bone homeostasis

    Polypeptides: Cannabinoid receptor 1, Cannabinoid receptor 2Function: cannabinoid receptor activity, cannabinoid receptor activity
  5. Target

    Folate receptor

    go.drugbank.com/bio_entities/BE0010260
    TransporterTargetHumans

    Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release … Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (PubMed:8567728).

    Polypeptides: Folate receptor alpha, Folate receptor betaSynonyms: Folate receptor 1, Folate receptor 2
  6. Target

    Adenosine receptor

    go.drugbank.com/bio_entities/BE0010284
    TargetHumans

    Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase … Receptor for adenosine (PubMed:29925945). The activity of this receptor is mediated by G proteins such as GNAI2 which inhibit adenylyl cyclase

    Polypeptides: Adenosine receptor A1, Adenosine receptor A2aFunction: G protein-coupled adenosine receptor activity, G protein-coupled adenosine receptor activity
  7. Target

    Apelin receptor

    go.drugbank.com/bio_entities/BE0013166
    TargetHumans

    May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). … G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis

    Polypeptides: Apelin receptorSynonyms: Angiotensin receptor-like 1, G protein-coupled receptor APJ
  8. Drug

    Tibolone

    go.drugbank.com/drugs/DB09070
    ApprovedInvestigational

    In June 2006, Organon Pharmaceuticals announced the receipt of a Not Approvable Letter from the U.S. … Tibolone is a synthetic steroid hormone drug, which is mainly non-selective in its binding profile, acting as an agonist primarily at estrogen receptors (ER), with a preference for ER alpha [L1874].

    Categories: Estrogen Receptor Modulators
  9. Drug

    Human vaccinia virus immune globulin

    go.drugbank.com/drugs/DB14112
    ApprovedInvestigational

    Nevertheless, VIG by virtue of the way it is produced is a poorly characterized and highly variable human product that is only available in very limited quantities - all factors that may intervene with

  10. Indication

    Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma

    go.drugbank.com/conditions/DBCOND0162925
    Drugs: Sacituzumab govitecan
    Synonyms: Locally Advanced Unresectable Hormone Receptor-Positive Breast Carcinoma, Unresectable, locally advanced Hormone Receptor Positive Breast Carcinoma