Apelin receptor

Details

Name
Apelin receptor
Kind
protein
Synonyms
  • AGTRL1
  • Angiotensin receptor-like 1
  • APJ
  • G-protein coupled receptor APJ
  • G-protein coupled receptor HG11
Gene Name
APLNR
UniProtKB Entry
P35414Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0013922|Apelin receptor
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREK
RRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCL
TGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQ
CYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGL
RKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYV
NSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGK
GGEQMHEKSIPYSQETLVVD
Number of residues
380
Molecular Weight
42660.055
Theoretical pI
Not Available
GO Classification
Not Available
General Function
Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936)
Specific Function
apelin receptor activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
27-51 67-91 101-125 145-166 201-221 245-271 285-308
Cellular Location
Cell membrane
Gene sequence
Not Available
Chromosome Location
11
Locus
11q12.1
External Identifiers
ResourceLink
UniProtKB IDP35414
UniProtKB Entry NameAPJ_HUMAN
GeneCard IDAPLNR
HGNC IDHGNC:339
PDB ID(s)2LOT, 2LOU, 2LOV, 2LOW, 5VBL, 6KNM, 7SUS, 7W0L, 7W0M, 7W0N, 7W0O, 7W0P, 8XZF, 8XZG, 8XZH, 8XZI, 8XZJ
KEGG IDhsa:187
IUPHAR/Guide To Pharmacology ID36
NCBI Gene ID187
General References
Not Available

Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
AzelapraginvestigationalyestargetagonistDetails