Apelin receptor

BE0013166ProteinHumansAPLNR

G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:11090199, PubMed:22810587, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). It is acted on by 2 drugs in DrugBank.

Gene name
APLNR
UniProtKB entry
P35414Swiss-Prot
Cellular location
Cell membrane
Residues / weight
380 residues · 42,660 Da
Also known as
AGTRL1 · Angiotensin receptor-like 1 · APJ · G protein-coupled receptor APJ · G protein-coupled receptor HG11

Resolves to

Protein
UniProtP35414UniProt nameAPJ_HUMAN
Gene
HGNCHGNC:339NCBI Gene187GeneCardsAPLNR
Pharmacology
IUPHAR/GtoPdb36KEGGhsa:187
Structure
PDB2LOTPDB2LOUPDB2LOV
Drugs

What you can answer from here — as of September 03, 2024

2DrugsApproved to experimental, with action, bond type and pharmacological action
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4GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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3+ReferencesStructured and connected to the statements they support
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Which compounds in development act on Apelin receptor, and which indications are they being tested in?

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