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Givosiran
go.drugbank.com/drugs/DB15066Approved[L10202] It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a genetic disorder … Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway.
Gallium nitrate
go.drugbank.com/drugs/DB05260ApprovedInvestigational[A17097] GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US for reasons other than safety or effectiveness. … Gallium nitrate is a nitrate salt of [DB14524], a heavy metal that has been used as a diagnostic agent.[A260816] Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone.
Cyclacillin
go.drugbank.com/drugs/DB01000ApprovedA cyclohexylamido analog of penicillanic acid.
Categories: Antibacterials for Systemic Use, Antiinfectives for Systemic UseTapinarof
go.drugbank.com/drugs/DB06083ApprovedInvestigationalTapinarof is a novel, first-in-class, small-molecule AhR agonist that is indicated for the treatment of adult psoriasis. … It is available as a topical cream to be applied to the affected area once daily.
Categories: Antipsoriatics for Topical UsePralsetinib
go.drugbank.com/drugs/DB15822ApprovedInvestigationalPralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes. … [A202049, A202055, L15986] Although a phase 1/2 trial of pralsetinib termed ARROW (NCT03037385) is still ongoing, pralsetinib was granted accelerated FDA approval on September 4, 2020, for the treatment
Potassium perchlorate
go.drugbank.com/drugs/DB09418ApprovedWithdrawnThe therapeutic use of potassium perchlorate in thyroid disorders has been ceased due to a high risk for developing aplastic anemia and nephrotic syndrome [L2364]. … The use of potassium perchlorate as a component in sealing gaskets for food containers has been revoked by the FDA following the use being abandoned by the industry [L2365].
Epcoritamab
go.drugbank.com/drugs/DB16672ApprovedInvestigationalAlthough this regimen is effective in up to 60% of patients, patients with relapsed or refractory DLBCL have poor outcomes. … [L46516] It is administered subcutaneously and is currently being evaluated as a monotherapy and in combination for the treatment of a variety of hematologic malignancies.
Levocabastine
go.drugbank.com/drugs/DB01106ApprovedLevocabastine is a selective second-generation H1-receptor antagonist used for allergic conjunctivitis. Levocabastine was discovered at Janssen Pharmaceutica in 1979.
Naldemedine
go.drugbank.com/drugs/DB11691ApprovedInvestigationalNaldemedine was approved in 2017 in both the US and Japan for the treatment of Opioid-induced Constipation. … It is a modified form of [DB00704] to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier.
Categories: Drugs for Constipation, Heterocyclic Compounds with 4 or More RingsGemcitabine
go.drugbank.com/drugs/DB00441ApprovedInvestigationalGemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers. … [A233135] Gemcitabine is a cytidine analog with two fluorine atoms replacing the hydroxyl on the ribose.
Categories: P-glycoprotein substrates with a Narrow Therapeutic IndexProducts: PAMIGEN® 200MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIONINYECTABLE, VIRULIZIN® 1G POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCIÓN INYECTABLE