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Dextran
go.drugbank.com/drugs/DB09255ApprovedInvestigationalVet approved[A32011] Many bacteria, like _Leuconostoc_, can synthesize dextran from sucrose, and this activity is used commercially to obtain dextran. … It is administered by intravenous infusion. Dextran 75 is a complex branched glucan with an average molecular weight 75000 Daltons.
Alirocumab
go.drugbank.com/drugs/DB09302ApprovedInvestigationalFrom this family, it was the first agent to receive FDA approval. The FDA approval was contingent on the completion of further clinical trials to better determine efficacy and safety. … Alirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of
Pexidartinib
go.drugbank.com/drugs/DB12978ApprovedInvestigational[L7901] Tenosynovial giant cell tumor is a rare form of non-malignant tumor that causes the synovium and tendon sheaths to thicken and overgrow, leading to damage in surrounding joint tissue. … In clinical trials, pexidartinib was shown to promote improvements in patient symptoms and functional outcomes in TGCT.
Garetosmab
go.drugbank.com/drugs/DB16379ApprovedInvestigational[L63940] Garetosmab-grts was approved by the FDA on August 19, 2026 to reduce the number of new heterotopic ossification lesions and clinician-assessed flare-ups in adults with FOP. … Garetosmab-grts is an activin A inhibitor used to treat fibrodysplasia ossificans progressiva (FOP).
Spironolactone
go.drugbank.com/drugs/DB00421ApprovedInvestigational[A178135, A261025] Spironolactone was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.[A178243] … [A11837, A178246] It is indicated to treat several conditions, including heart failure, edema, hyperaldosteronism, and hypertension.
Cefditoren
go.drugbank.com/drugs/DB01066ApprovedIt is commonly marketed under the trade name Spectracef by Cornerstone BioPharma.
Iodine povacrylex
go.drugbank.com/drugs/DB09537ApprovedDuraPrep solution is indicated for use as a patient preoperative skin preparation, for the preparation of the skin prior to surgery and to help reduce bacteria that can potentially cause skin infection … Prolonged skin exposure could cause skin defatting manifested by the following signs/symptoms; localized redness, itching, drying and cracking of skin.
Olaparib
go.drugbank.com/drugs/DB09074ApprovedInvestigational[A246015] Olaparib is used to treat a number of BRCA-associated tumours, including ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. … [L41100, L40908, L43792] It was first approved by the FDA and EU in December 2014,[A246020] and by Health Canada in April 2016.[L42820]
Topiramate
go.drugbank.com/drugs/DB00273ApprovedInvestigationalTopiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996. … [A175249] Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.[A188330]
Synonyms: 2,3:4,5-di-O-isopropylidene-β-D-fructopyranose sulfamate, 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamatePibrentasvir
go.drugbank.com/drugs/DB13878ApprovedInvestigationalMavyret is also indicated for HCV genotype 1-infected patients who have been previously treated with regimens either containing an NS5A inhibitor or an NS3/4A protease inhibitor, but not both [L940]. … In cell cultures, the emergence of amino acid substitutions at known NS5A inhibitor resistance-associated positions in HCV genotype 1a, 2a or 3a replicons led to reduced susceptibility and resistance to