Iodine povacrylex

Identification

Summary

Iodine povacrylex is an antiseptic agent used for disinfection of the skin prior to surgical procedures to prevent bacterial skin infections.

Brand Names
Duraprep
Generic Name
Iodine povacrylex
DrugBank Accession Number
DB09537
Background

Iodine povacrylex (DuraPrep) is a surgical solution, film-forming iodophor complex that provides fast acting, persistent, broad-spectrum antimicrobial activity. DuraPrep solution is indicated for use as a patient preoperative skin preparation, for the preparation of the skin prior to surgery and to help reduce bacteria that can potentially cause skin infection. It is a broad spectrum antiseptic and can provide almost 99.9% antiseptic conditions. It is intended for local use only. Prolonged skin exposure could cause skin defatting manifested by the following signs/symptoms; localized redness, itching, drying and cracking of skin.

Type
Small Molecule
Groups
Approved
Synonyms
  • Iodine povacrylex

Pharmacology

Indication

Antispetic and germicidal agent. It is indicated for use as a patient preoperative skin preparation, for the preparation of the skin prior to surgery and to help reduce bacteria that can potentially cause skin infection.

Pharmacology
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Associated Therapies
Contraindications & Blackbox Warnings
Contraindications
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Pharmacodynamics

Microbial reduction of the skin ideally kills all skin organisms.

Mechanism of action

Killing microorganisms by denaturation of proteins in its fluid state through oxidation after penetration of the cell wall.

Absorption

For local use only, no systemic absorption.

Volume of distribution

For local use only, no systemic absorption.

Protein binding

For local use only, no systemic absorption.

Metabolism

For local use only, no systemic absorption.

Route of elimination

For local use only, no systemic absorption.

Half-life

For local use only, no systemic absorption.

Clearance

For local use only, no systemic absorption.

Adverse Effects
Medicalerrors
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Toxicity

No data available; calculated acute toxicity estimate: 2,000 - 5,000 mg/kg.

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

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Active Moieties
NameKindUNIICASInChI Key
Iodineunknown9679TC07X47553-56-2PNDPGZBMCMUPRI-UHFFFAOYSA-N
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
3M DuraPrep SurgicalIodine povacrylex (6.02 mg/1mL) + Isopropyl alcohol (636.4 mg/1mL)SolutionTopical3M Company2006-09-29Not applicableUS flag

Categories

Drug Categories
Not Available
Classification
Not classified
Affected organisms
  • Fungi
  • Gram negative and gram positive bacteria
  • Various viruses

Chemical Identifiers

UNII
6E43AWY083
CAS number
845736-10-9
InChI Key
Not Available
InChI
Not Available
IUPAC Name
Not Available
SMILES
Not Available

References

General References
  1. FDA label [Link]
  2. MSDS [Link]
  3. article [Link]
PubChem Substance
347910459
RxNav
692863

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4RecruitingPreventionSurgical Site Infections1
Not AvailableCompletedPreventionSurgery, Colorectal1
Not AvailableCompletedTreatmentHip Arthroplasty / Postoperative Wound Infection1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
SolutionTopical
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Drug created on November 30, 2015 19:10 / Updated on February 21, 2021 18:52