Identification
- Summary
Iodine povacrylex is an antiseptic agent used for disinfection of the skin prior to surgical procedures to prevent bacterial skin infections.
- Brand Names
- Duraprep
- Generic Name
- Iodine povacrylex
- DrugBank Accession Number
- DB09537
- Background
Iodine povacrylex (DuraPrep) is a surgical solution, film-forming iodophor complex that provides fast acting, persistent, broad-spectrum antimicrobial activity. DuraPrep solution is indicated for use as a patient preoperative skin preparation, for the preparation of the skin prior to surgery and to help reduce bacteria that can potentially cause skin infection. It is a broad spectrum antiseptic and can provide almost 99.9% antiseptic conditions. It is intended for local use only. Prolonged skin exposure could cause skin defatting manifested by the following signs/symptoms; localized redness, itching, drying and cracking of skin.
- Type
- Small Molecule
- Groups
- Approved
- Synonyms
- Iodine povacrylex
Pharmacology
- Indication
Antispetic and germicidal agent. It is indicated for use as a patient preoperative skin preparation, for the preparation of the skin prior to surgery and to help reduce bacteria that can potentially cause skin infection.
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- Contraindications & Blackbox Warnings
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Microbial reduction of the skin ideally kills all skin organisms.
- Mechanism of action
Killing microorganisms by denaturation of proteins in its fluid state through oxidation after penetration of the cell wall.
- Absorption
For local use only, no systemic absorption.
- Volume of distribution
For local use only, no systemic absorption.
- Protein binding
For local use only, no systemic absorption.
- Metabolism
For local use only, no systemic absorption.
- Route of elimination
For local use only, no systemic absorption.
- Half-life
For local use only, no systemic absorption.
- Clearance
For local use only, no systemic absorption.
- Adverse Effects
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No data available; calculated acute toxicity estimate: 2,000 - 5,000 mg/kg.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
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Name Kind UNII CAS InChI Key Iodine unknown 9679TC07X4 7553-56-2 PNDPGZBMCMUPRI-UHFFFAOYSA-N - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 3M DuraPrep Surgical Iodine povacrylex (6.02 mg/1mL) + Isopropyl alcohol (636.4 mg/1mL) Solution Topical 3M Company 2006-09-29 Not applicable US 
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Fungi
- Gram negative and gram positive bacteria
- Various viruses
Chemical Identifiers
- UNII
- 6E43AWY083
- CAS number
- 845736-10-9
- InChI Key
- Not Available
- InChI
- Not Available
- IUPAC Name
- Not Available
- SMILES
- Not Available
References
- General References
- External Links
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Terminated Prevention Surgical Site Infections 1 Not Available Completed Prevention Surgery, Colorectal 1 Not Available Completed Treatment Hip Arthroplasty / Postoperative Wound Infection 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Solution Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Not Available
- Experimental Properties
- Not Available
- Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
Drug created at November 30, 2015 19:10 / Updated at February 21, 2021 18:52