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Enzalutamide
go.drugbank.com/drugs/DB08899ApprovedInvestigational[A252667,A252642] Due to a favorable pharmacological profile, a phase 1 study of enzalutamide was initiated in July 2007. … [L40639] It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: XTANDI ® 40 MG, XTANDI® 40 MGRaxibacumab
go.drugbank.com/drugs/DB08902ApprovedInvestigationalRaxibacumab is a human IgG1λ monoclonal antibody that binds the protective antigen (PA) component of B. anthracis toxin. Raxibacumab has a molecular weight of approximately 146 kilodaltons. … Raxibacumab is produced by recombinant DNA technology in a murine cell expression system. FDA approved on December 14, 2012.
Formestane
go.drugbank.com/drugs/DB08905ApprovedWithdrawnIt is listed as a prohibited substance by the World Anti-Doping Agency for use in athletes. … Formestane is also a prohormone of 4-hydroxytestosterone, an active steroid with weak androgenic activity and mild aromatase inhibitor activity.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersSynonyms: 4-OH-A, 4-hydroxy-4-androstene-3,17-dioneFluticasone furoate
go.drugbank.com/drugs/DB08906ApprovedInvestigationalFluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications[FDA Label][F4364]. Fluticasone furoate was first approved in 2007[L5965].
Mixtures: RELVAR® ELLIPTA® 100MCG/25MCG, RELVAR® ELLIPTA ® 200MCG/25MCG POLVO PARA INHALACIÓNCategories: P-glycoprotein inducers, P-glycoprotein substratesAleglitazar
go.drugbank.com/drugs/DB08915InvestigationalAleglitazar is an investigational drug from the company Hoffmann–La Roche and is currently in a phase III clinical trial called ALECARDIO. … It is being investigated for use in patients with type II diabetes to reduce their risks of cardiovascular mortality and morbidity.
Categories: Heterocyclic Compounds, 1-Ring(4R)-limonene
go.drugbank.com/drugs/DB08921InvestigationalAs the main odor constituent of citrus (plant family Rutaceae), D-limonene is used in food manufacturing and some medicines, e.g. as a flavoring to mask the bitter taste of alkaloids, and as a fragrant … Limonene is common in cosmetic products.
Synonyms: (R)-4-isopropenyl-1-methyl-1-cyclohexene, (R)-1-methyl-4-(1-methylethenyl)cyclohexeneChlorcyclizine
go.drugbank.com/drugs/DB08936ApprovedChlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. … Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.
Mixtures: biclora-D, biclora-DCategories: Heterocyclic Compounds, 1-RingTAS-102
go.drugbank.com/drugs/DB08937InvestigationalTAS-102 (Taiho Pharma USA, Inc.) is an anti-cancer drug under development and in stage 3 clinical trials for the treatment of colorectal cancer. … It is composed of the thymidine phosphorylase inhibitor (TPI) tipiracil and the cytotoxin trifluridine. Trifluridine inhibits tumor growth by being incorporated into DNA during DNA synthesis.
Categories: Heterocyclic Compounds, 1-RingIsoxsuprine
go.drugbank.com/drugs/DB08941ApprovedWithdrawnIt is used in the treatment of peripheral vascular disease and in premature labor. … A beta-adrenergic agonist that causes direct relaxation of uterine and vascular smooth muscle.
Categories: 2-Amino-1-Phenylethanol DerivativesIsoxicam
go.drugbank.com/drugs/DB08942ApprovedWithdrawnIsoxicam is a non-steroidal anti-inflammatory drug that is not marketed in the United States.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-Ring