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Lanolin
go.drugbank.com/drugs/DB11112ApprovedThe US federal code of regulations states that lanolin in the concentration range of 12-50% may be included in over the counter skin ointments [L2583]. … Lanolin is the purified, secreted product of the sheep sebaceous glands [L2584]. Lanolin primarily consists of long-chain waxy esters, or sterol esters, that lack glycerides.
Mixtures: Veradex-E, Huile De Bain TherapeutiquePhentermine
go.drugbank.com/drugs/DB00191ApprovedIllicitInvestigational[A174370] Phentermine has not been reported an addictive potential which allows this agent to be classified under the Schedule IV drugs (low abuse potential). … [A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: TERFAMEX TCertolizumab pegol
go.drugbank.com/drugs/DB08904ApprovedInvestigationalThe absence of the Fc region was ideated to prevent complement fixation and antibody-mediated cytotoxicity as well as to markedly increase its half-life. … [A176585] It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region.
Categories: Tumor Necrosis Factor Receptor Blocking ActivityEtoricoxib
go.drugbank.com/drugs/DB01628ApprovedInvestigationalWithdrawnIt is approved in more than 60 countries worldwide but not in the US. … Like any other COX-2 selective inhibitor, Etoricoxib selectively inhibits isoform 2 of cyclo-oxigenase enzyme (COX-2) to reduce the generation of prostaglandins (PGs) from arachidonic acid.
Mixtures: ETRAL - TREnflurane
go.drugbank.com/drugs/DB00228ApprovedVet approvedWithdrawnIn addition, it is known to cause increased cardio depressant effects when compared to other inhaled anesthetics.[A202022] … Enflurane is a halogenated inhalational anesthetic initially approved by the FDA in 1972. Since this date, it has been withdrawn from the US market.
Buprenorphine
go.drugbank.com/drugs/DB00921ApprovedIllicitInvestigationalVet approved[A186292] This means that buprenorphine preferentially binds the opioid receptor and displaces lower affinity opioids without activating the receptor to a comparable degree. … Buprenorphine is a weak partial mu-opioid receptor agonist and a weak kappa-opioid receptor antagonist used for the treatment of severe pain.
Mixtures: BUPRENORFINA E NALOXONE ETHYPHARM, BUPRENORFINA E NALOXONE ETHYPHARMCategories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSucralfate
go.drugbank.com/drugs/DB00364ApprovedInvestigationalIt was approved by the FDA 1982 in tablet form, and in 1994 for the suspension form [L6073, L6076]. … Sucralfate has been shown to be a well-tolerated and safe drug. It is sold under many brands and is available in both tablet and suspension forms.
Levoleucovorin
go.drugbank.com/drugs/DB11596ApprovedInvestigationalIn vitro, the levo-isomer has been shown to be rapidly converted to the biologically available methyl-tetrahydrofolate form while the dextro form is slowly excreted by the kidneys. … However, in order to function in this role, it must first be reduced by the enzyme dihydrofolate reductase (DHFR) into the cofactors dihydrofolate (DHF) and tetrahydrofolate (THF).
Gadodiamide
go.drugbank.com/drugs/DB00225ApprovedInvestigational[A263096] Approved by the FDA in 1993, gadodiamide is the first non-ionic GBCA to be used. … [A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agents.
Nabilone
go.drugbank.com/drugs/DB00486ApprovedInvestigationalWhile both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects. … Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers.