Explore a selection of our essential drug information below, or:
Identification
- Summary
Lanolin is an ingredient used in skin care products to relieve irritation.
- Brand Names
- Calmoseptine Ointment, Lana1263, Lantiseptic, Systane
- Generic Name
- Lanolin
- DrugBank Accession Number
- DB11112
- Background
Lanolin is a yellow fat obtained from sheep's wool. It is used as an emollient, cosmetic, and pharmaceutic aid 6. The US federal code of regulations states that lanolin in the concentration range of 12-50% may be included in over the counter skin ointments 9.
Lanolin is the purified, secreted product of the sheep sebaceous glands 10. Lanolin primarily consists of long-chain waxy esters, or sterol esters, that lack glycerides. For this reason, it is also called wool wax or wool grease. Lanolin is used in the protection, treatment, and cosmetic enhancement of human skin. Its hydrophobic properties can help protect skin against infections or skin irritation, as it helps seal in moisture that is already present in the skin 13.
Lanolin is used as an active ingredient in over the counter topical products such as ointments, lubricants, lotions and facial cosmetics. Lanolin is also frequently used in protective baby skin treatment and for sore nipples in breastfeeding mothers 9, 1.
- Type
- Small Molecule
- Groups
- Approved
- Synonyms
- Anhydrous lanolin
- Fats, lanolin
- Lanolin
- Lanolin oil
- Lanolin, anhydrous
- Wool fat
- Wool grease
- Wool oil
- Wool wax, lanolin
- Wool wax, refined
Pharmacology
- Indication
Used as a skin protectant, and to relieve dryness and irritation of the skin 12, 7. Helps prevent and treat diaper dermatitis 5.
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- Contraindications & Blackbox Warnings
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Lanolin treats cracked, dry, irritated skin and minor burns. It prevents and treats sore nipples during breastfeeding 4, 15. Protects chafed skin or minor skin irritations due to various causes 5, 7.
- Mechanism of action
Lanolin is an emollient. Emollients soften the skin by forming an occlusive oil film on the stratum corneum layer of the epithelium, thus decreasing the transepidermal water loss 7.
- Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
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Studies have shown a positive association between atopic dermatitis and lanolin contact allergy 14. The prevalence of lanolin allergy is low (1.8%-2.5%) 1. Patch testing with lanolin is helpful in patients with dermatitis and suspected cosmetic allergy 14.
The acute dermal LD50 of lanolin oil was > 10 mL/kg for rabbits 18.
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- Over the Counter Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image 3ce Drawing Lip Chilling Lipstick 0.02 g/1.1g Topical Nanda Co., Ltd. 2016-08-01 Not applicable US 
4sport Skincare Anti Chafing Lotion 40 g/100mL Topical 4sport d.o.o. 2018-01-07 Not applicable US AmeriDerm DermaFix Ointment 22 g/100g Topical Shield Line LLC 2015-02-01 Not applicable US Black Rose Ointment 249.1 mg/1g Topical MAKRA KOZMETIKA D.O.O. 2022-09-01 Not applicable US Lana1263 Ointment 50 g/100g Topical Blossom Pharmaceuticals 2014-10-23 Not applicable US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image A and D Diaper Rash and Skin Protectant Lanolin (0.15 mg/1g) + Petrolatum (0.53 mg/1g) Cream Topical Natureplex, LLC 2014-11-12 Not applicable US A and D First Aid Lanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g) Ointment Topical Bayer Healthcare Llc. 2003-06-04 Not applicable US A and D First Aid Lanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g) Ointment Topical Delpharm Montreal Inc. 2003-06-04 Not applicable US A and D Original Lanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g) Ointment Topical Delpharm Montreal Inc. 2003-06-04 Not applicable US A and D Original Lanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g) Ointment Topical Bayer Healthcare Llc. 2003-06-04 Not applicable US - Unapproved/Other Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image 3ce Drawing Lip Chilling Lanolin (0.02 g/1.1g) Lipstick Topical Nanda Co., Ltd. 2016-08-01 Not applicable US Baby Butz Lanolin (8.8 g/57g) + Starch, corn (14.3 g/57g) + Zinc oxide (17.1 g/57g) Cream Topical Olen Cosmetics Corporation 2012-07-17 2013-07-08 US
Categories
- Drug Categories
- Classification
- Not classified
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- 7EV65EAW6H
- CAS number
- 8006-54-0
References
- General References
- Miest RY, Yiannias JA, Chang YH, Singh N: Diagnosis and prevalence of lanolin allergy. Dermatitis. 2013 May-Jun;24(3):119-23. doi: 10.1097/DER.0b013e3182937aa4. [Article]
- Hon KL, Kung JSC, Ng WGG, Leung TF: Emollient treatment of atopic dermatitis: latest evidence and clinical considerations. Drugs Context. 2018 Apr 17;7:212530. doi: 10.7573/dic.212530. eCollection 2018. [Article]
- Code of federal regulations [Link]
- NIH: Lanolin on the skin [Link]
- Lanolin Ointment [Link]
- Lanolin MeSH [Link]
- Lanolin synthesis reference [Link]
- Lanolin, Drugs.com [Link]
- NIH Toxnet Lanolin [Link]
- Final Report of the Safety Assessment for PEG-75 Lanolin, PEG-20 Lanolin, PEG-27 Lanolin, PEG-30 Lanolin, PEG-40 Lanolin, PEG-50 Lanolin, PEG-60 Lanolin, and PEG-85 Lanolin [Link]
- LipidBank Wax [Link]
- Lanolin Monograph, Epocrates [Link]
- Lanolin, Web MD [Link]
- Contact allergy to lanolin: temporal changes in prevalence and association with atopic dermatitis [Link]
- An evaluation of the effect ov lanolin in healing nipple injuries [Link]
- Alpha Keri Skincare Product Information [Link]
- TITCK Product Information: Duratears ophthalmic ointment [Link]
- Safety Assessment of Polyether Lanolins as Used in Cosmetics [File]
- External Links
- MSDS
- Download (66.8 KB)
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample data4 Completed Treatment Diaper Rash 1 somestatus stop reason just information to hide 3 Completed Treatment Incontinence Associated Dermatitis 1 somestatus stop reason just information to hide 3 Completed Treatment Postoperative Radiotherapy Breast Cancer 1 somestatus stop reason just information to hide 2 Completed Prevention Breastfeeding 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
Form Route Strength Lipstick Topical 0.02 g/1.1g Lotion Topical 40 g/100mL Ointment Topical 249.1 mg/1g Paste Topical Kit Topical Cream Topical Ointment Rectal; Topical Solution Topical Ointment Topical 50 g/100g Ointment Topical 0.3 g/100g Cream Topical 370 mg/1g Ointment Topical 70 g / 100 g Ointment Topical 72 % Cream Topical 500 mg/1g Cream Topical 300 mg/1g Ointment Topical 22 g/100g Lipstick Cutaneous 1 mg/5mg Lipstick Cutaneous 1.5 mg/5mg Ointment Ophthalmic Ointment Topical 300 mg/1g Ointment Topical 5 g/10g Liquid Topical Cream Topical 50 g/100g Cream Topical 1 mg/50mg Ointment Topical 500 mg/1g Lotion Topical Liquid Topical 12.5 g/100mL Ointment Topical 350.8 mg/1g Ointment Topical - Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 38-44 MSDS water solubility insoluble MSDS - Predicted Properties
- Not Available
- Predicted ADMET Features
- Not Available
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Drug created at December 03, 2015 16:51 / Updated at October 13, 2024 00:22