Identification

Name
Lanolin
Accession Number
DB11112
Description

Lanolin is a yellow fat obtained from sheep's wool. It is used as an emollient, cosmetic, and pharmaceutic aid 6. The US federal code of regulations states that lanolin in the concentration range of 12-50% may be included in over the counter skin ointments 9.

Lanolin is the purified, secreted product of the sheep sebaceous glands 10. Lanolin primarily consists of long-chain waxy esters, or sterol esters, that lack glycerides. For this reason, it is also called wool wax or wool grease. Lanolin is used in the protection, treatment, and cosmetic enhancement of human skin. Its hydrophobic properties can help protect skin against infections or skin irritation, as it helps seal in moisture that is already present in the skin 13.

Lanolin is used as an active ingredient in over the counter topical products such as ointments, lubricants, lotions and facial cosmetics. Lanolin is also frequently used in protective baby skin treatment and for sore nipples in breastfeeding mothers 9, 1.

Type
Small Molecule
Groups
Approved
Synonyms
  • Anhydrous lanolin
  • Fats, lanolin
  • Lanolin oil
  • Lanolin, anhydrous
  • Wool fat
  • Wool grease
  • Wool oil
  • Wool wax, lanolin
  • Wool wax, refined

Pharmacology

Indication

Used as a skin protectant, and to relieve dryness and irritation of the skin 12, 7. Helps prevent and treat diaper dermatitis 5.

Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
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Pharmacodynamics

Lanolin treats cracked, dry, irritated skin and minor burns. It prevents and treats sore nipples during breastfeeding 4, 15. Protects chafed skin or minor skin irritations due to various causes 5, 7.

Mechanism of action

Lanolin is an emollient. Emollients soften the skin by forming an occlusive oil film on the stratum corneum layer of the epithelium, thus decreasing the transepidermal water loss 7.

TargetActionsOrganism
ASkin epithelial cells
coating agent
Humans
Absorption
Not Available
Volume of distribution
Not Available
Protein binding
Not Available
Metabolism
Not Available
Route of elimination
Not Available
Half-life
Not Available
Clearance
Not Available
Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More
Toxicity

Studies have shown a positive association between atopic dermatitis and lanolin contact allergy 14. The prevalence of lanolin allergy is low (1.8%-2.5%) 1. Patch testing with lanolin is helpful in patients with dermatitis and suspected cosmetic allergy 14.

The acute dermal LD50 of lanolin oil was > 10 mL/kg for rabbits 16.

Affected organisms
  • Humans and other mammals
Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
No interactions found.

Products

Over the Counter Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
3ce Drawing Lip ChillingLipstick0.02 g/1.1gTopicalNanda Co., Ltd.2016-08-01Not applicableUS flag
4sport Skincare Anti ChafingLotion40 g/100mLTopical4sport d.o.o.2018-01-07Not applicableUS flag
AmeriDerm DermaFixOintment22 g/100gTopicalShield Line LLC2015-02-01Not applicableUS flag
Lana1263Ointment50 g/100gTopicalBlossom Pharmaceuticals2014-10-23Not applicableUS flag
LanashieldOintment50 g/100gTopicalDynarex Corporation2014-10-12Not applicableUS flag
LanodermOintment0.3 g/100gTopicalDermarite Industries LLC2012-04-16Not applicableUS flag
LanoGuard Daily Care Skin ProtectantOintment300 mg/1gTopicalSummit Industries2013-03-21Not applicableUS flag
LanoGuard Dry Skin TherapyCream370 mg/1gTopicalSummit Industries2009-12-30Not applicableUS flag
LanolinOintment50 g/100gTopicalSion Biotext Medical Ltd2012-07-09Not applicableUS flag
LanolinOintment70 gTopicalDrug Trading Company Ltd.1951-12-311998-07-07Canada flag
Additional Data Available
  • Application Number
    Application Number

    A unique ID assigned by the FDA when a product is submitted for approval by the labeller.

    Learn more
  • Product Code
    Product Code

    A governmentally-recognized ID which uniquely identifies the product within its regulatory market.

    Learn more
Mixture Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
A and D Diaper Rash and Skin ProtectantLanolin (0.15 mg/1g) + Petrolatum (0.53 mg/1g)CreamTopicalNatureplex, LLC2014-11-12Not applicableUS flag
A and D First AidLanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g)OintmentTopicalBayer HealthCare LLC2003-06-04Not applicableUS flag
A and D First AidLanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g)OintmentTopicalDelpharm Montreal Inc.2003-06-04Not applicableUS flag
A and D OriginalLanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g)OintmentTopicalDelpharm Montreal Inc.2003-06-04Not applicableUS flag
A and D OriginalLanolin (136.4 mg/1g) + Petrolatum (469.9 mg/1g)OintmentTopicalBayer Healthcare Llc.2003-06-04Not applicableUS flag
A D and L Original Diaper Rash SkinLanolin (15.5 g/100g) + Petrolatum (53.4 g/100g)OintmentTopicalHarmon Stores2014-09-01Not applicableUS flag
A+d Diaper Rash OintmentLanolin (15.5 %) + Petrolatum (53.4 %)OintmentTopicalSchering Plough1998-07-082014-07-31Canada flag
Alpha KeriLanolin (3 %) + Mineral oil (91.7 %)LiquidTopicalBristol Myers Squibb1958-12-311999-08-09Canada flag
Baby BumLanolin (0.5 g/1g) + Zinc oxide (0.125 g/1g)PasteTopicalBlairs Ferry Pharmacy2019-06-26Not applicableUS flag
Baby ButzLanolin (8.8 g/57g) + Starch, corn (14.3 g/57g) + Zinc oxide (17.1 g/57g)CreamTopicalOlen Cosmetics Corporation2012-07-172013-07-08US flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
3ce Drawing Lip ChillingLanolin (0.02 g/1.1g)LipstickTopicalNanda Co., Ltd.2016-08-01Not applicableUS flag
Baby ButzLanolin (8.8 g/57g) + Starch, corn (14.3 g/57g) + Zinc oxide (17.1 g/57g)CreamTopicalOlen Cosmetics Corporation2012-07-172013-07-08US flag

Categories

Drug Categories
Classification
Not classified

Chemical Identifiers

UNII
7EV65EAW6H
CAS number
8006-54-0

References

General References
  1. Miest RY, Yiannias JA, Chang YH, Singh N: Diagnosis and prevalence of lanolin allergy. Dermatitis. 2013 May-Jun;24(3):119-23. doi: 10.1097/DER.0b013e3182937aa4. [PubMed:23665833]
  2. Hon KL, Kung JSC, Ng WGG, Leung TF: Emollient treatment of atopic dermatitis: latest evidence and clinical considerations. Drugs Context. 2018 Apr 17;7:212530. doi: 10.7573/dic.212530. eCollection 2018. [PubMed:29692852]
  3. Code of federal regulations [Link]
  4. NIH: Lanolin on the skin [Link]
  5. Lanolin Ointment [Link]
  6. Lanolin MeSH [Link]
  7. Lanolin synthesis reference [Link]
  8. Lanolin, Drugs.com [Link]
  9. NIH Toxnet Lanolin [Link]
  10. Final Report of the Safety Assessment for PEG-75 Lanolin, PEG-20 Lanolin, PEG-27 Lanolin, PEG-30 Lanolin, PEG-40 Lanolin, PEG-50 Lanolin, PEG-60 Lanolin, and PEG-85 Lanolin [Link]
  11. LipidBank Wax [Link]
  12. Lanolin Monograph, Epocrates [Link]
  13. Lanolin, Web MD [Link]
  14. Contact allergy to lanolin: temporal changes in prevalence and association with atopic dermatitis [Link]
  15. An evaluation of the effect ov lanolin in healing nipple injuries [Link]
  16. Safety Assessment of Polyether Lanolins as Used in Cosmetics [File]
PubChem Substance
347911120
RxNav
6227
Wikipedia
Lanolin
AHFS Codes
  • 84:24.12 — Basic Ointments and Protectants
MSDS
Download (66.8 KB)

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
3CompletedTreatmentPostoperative Radiotherapy Breast Cancer1
2RecruitingPreventionBreastfeeding1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
LipstickTopical0.02 g/1.1g
LotionTopical40 g/100mL
PasteTopical
KitTopical
CreamTopical
OintmentOphthalmic3 %
OintmentRectal; Topical
SolutionTopical
OintmentTopical50 g/100g
OintmentTopical0.3 g/100g
CreamTopical370 mg/1g
OintmentTopical70 g
OintmentTopical
CreamTopical500 mg/1g
CreamTopical300 mg/1g
OintmentTopical22 g/100g
OintmentTopical300 mg/1g
OintmentTopical5 g/10g
LiquidTopical
CreamTopical50 g/100g
CreamTopical1 mg/50mg
OintmentTopical500 mg/1g
OintmentOphthalmic
LotionTopical
LiquidTopical12.5 g/100mL
OintmentTopical
Prices
Not Available
Patents
Not Available

Properties

State
Solid
Experimental Properties
PropertyValueSource
melting point (°C)38-44MSDS
water solubilityinsoluble MSDS
Predicted Properties
Not Available
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
Not Available

Targets

1. Skin epithelial cells
Kind
Group
Organism
Humans
Pharmacological action
Yes
Actions
Coating agent
References
  1. Lanolin synthesis reference [Link]

Drug created on December 03, 2015 09:51 / Updated on September 17, 2020 23:29

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