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Sulpiride
go.drugbank.com/drugs/DB00391ApprovedWithdrawn[A229538] Clinical studies show a greater effect on treating the negative symptoms of schizophrenia rather than positive symptoms at low doses, though the effects are more equal at higher doses. … [A229683] Sulpiride is not approved by the FDA, Health Canada, or the EMA; though it is approved in individual European countries.[L24679]
Mixtures: NEUPAX DUO-SCategories: MATE 1 Substrates, MATE 2 SubstratesBumetanide
go.drugbank.com/drugs/DB00887ApprovedInvestigationalBumetanide is a sulfamyl diuretic.
Synonyms: 3-butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid, 3-butylamino-4-phenoxy-5-sulfamoyl-benzoic acidMixtures: BURINEX TABLET 1 mg, BURINEX TABLET 1 mgTiaprofenic acid
go.drugbank.com/drugs/DB01600ApprovedIt belongs to the _arylpropionic acid_ (profen) group of nonsteroidal anti-inflammatory drugs (NSAIDs). … Tiaprofenic acid is a non-steroidal anti-inflammatory drug employed in the treatment of pain, particularly arthritis pain.
Synonyms: 2-(5-Benzyl-2-thienyl)propionsäure, 2-(5-Benzoyl-thiophen-2-yl)-propionic acidCategories: Non COX-2 selective NSAIDSArtemether
go.drugbank.com/drugs/DB06697ApprovedInvestigationalIt is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp. … </i> and may be used to treat infections caused by <i>P. falciparum</i> and unidentified <i>Plasmodium</i> species, including infections acquired in chloroquine-resistant areas.
Mixtures: COARTEM ® 20/120 MG COMPRIMIDOS, ARTELERIA (ARTEMETERO 20 MG Y LUMEFANTRINA 120 MG)Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 InducersTolcapone
go.drugbank.com/drugs/DB00323ApprovedInvestigationalWithdrawnIt is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. … Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication.
Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSynonyms: 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone, 3,4-dihydroxy-5-nitro-4'-methylbenzophenoneSecobarbital
go.drugbank.com/drugs/DB00418ApprovedVet approvedIt is commonly known as quinalbarbitone in the United Kingdom. … Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP1A2 InducersSynonyms: 5-(1-methylbutyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione, 5-allyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyran
go.drugbank.com/drugs/DB07700ExperimentalAcetazolamide
go.drugbank.com/drugs/DB00819ApprovedInvestigationalVet approvedIt is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A InhibitorsSynonyms: 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, 5-acetamido-1,3,4-thiadiazole-2-sulfonamideMethohexital
go.drugbank.com/drugs/DB00474ApprovedAn intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
Categories: Heterocyclic Compounds, 1-RingSynonyms: (±)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid, 5-allyl-1-methyl-5-(1-methyl-2-pentynyl)-2,4,6(1H,3H,5H)-pyrimidinetrioneCapecitabine
go.drugbank.com/drugs/DB01101ApprovedInvestigationalCapecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic IndexSynonyms: pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate, Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate