Methohexital

DB00474ApprovedSmall moleculeBarbiturates

Methohexital is an anesthetic used to induce deep sedation. An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.

Mechanism: Methohexital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Curator reviewed
Primary indication: Methohexital is indicated for use as an intravenous anaesthetic.Curator reviewed · 3 structured indications
Formula / weight: C₁₄H₁₈N₂O₃ · 262.3043 g/mol (avg)
First approval: Canada, 1960 · United States, 1960
Also known as: Methohexitone
Brand names: Brevital

Resolves to

Compound

UNIIE5B8ND5IPECAS151-83-7ChEMBLCHEMBL7413ChEBI102216PubChem9034KEGGD04985

Clinical / RWD

RxNorm6847ATCN01AF01ATCN05CA15ATCN05CB01PharmGKBPA164784030

Structure

InChIKeyNZXKDOXHBHYTKP-UHFFFAOYSA-NSMILESCCC#CC(C)C1(CC=C)C(=O)NC(=O)N(C)C1=O

Targets

P14867GABRA1

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

1,035Drug interactionsStructured to mechanism, not free text

10Clinical trialsPhase, status and sponsor resolved per trial

3Structured indicationsCondition, population, route and combination as fields, not prose

4ContraindicationsEach with its own population and attribute set

11Marketed productsAcross 3 countries and 10 labellers

3ATC codesIncluding every combination product, plus 14 drug categories

3+ReferencesStructured and connected to the statements they support

Which drugs share a target with Methohexital, and which of those have an active Phase 3 trial?

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