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Displaying results 1591 - 1600 of 3601 in total
  1. Drug

    Naproxen

    go.drugbank.com/drugs/DB00788
    ApprovedInvestigationalVet approved

    Naproxen is classified as a nonsteroidal anti-inflammatory dug (NSAID) and was initially approved for prescription use in 1976 and then for over-the-counter (OTC) use in 1994. It can effectively manage acute pain as well as pain related ...

    Mixtures: Aleve PM, Naproxen PMCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  2. Drug

    PF-04991532

    go.drugbank.com/drugs/DB11765
    Investigational

    PF-04991532 has been used in trials studying the basic science of Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2, and Glucose Metabolism Disorders.

  3. Drug

    PL-3994

    go.drugbank.com/drugs/DB15355
    Investigational

    PL-3994 is under investigation in clinical trial NCT01304628 (Cross-Over Study of Subcutaneous Study Drug for the Treatment of Patients With Mild to Moderate Asthma).

  4. Drug

    Talazoparib

    go.drugbank.com/drugs/DB11760
    ApprovedInvestigational

    Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib wa...

    Categories: P-glycoprotein substrates, P-glycoprotein substrates with a Narrow Therapeutic Index
  5. Drug

    Bezlotoxumab

    go.drugbank.com/drugs/DB13140
    Approved

    Bezlotoxumab is a fully humanized ImmunoglobulinG1 (IgG1) kappa monoclonal antibody that binds to Clostridium difficile toxin B and neutralizes its effects. First approved by the FDA on October 21, 2016, bezlotoxumab is used to reduce th...

  6. Target

    Glycine receptors

    go.drugbank.com/bio_entities/BE0009666
    TargetHumans

    Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contri...

    Synonyms: Glycine receptor 48 kDa subunit, Glycine receptor 58 kDa subunitPolypeptides: Glycine receptor subunit alpha-1, Glycine receptor subunit beta
  7. Drug

    OBE101

    go.drugbank.com/drugs/DB05080
    Experimental

    OBE101 is a new weight loss drug developed by Obecure Ltd. It is a new formulation that is based on the vertigo medication, Betahistine. … Obecure is repurposing betahistine, which is an H1 receptor agonist and partial H3 receptor antagonist for the treatment of obese individuals and for other weight management indications.

  8. Drug

    Dirocaftor

    go.drugbank.com/drugs/DB16143
    Investigational

    Dirocaftor is under investigation in clinical trial NCT03251092 (Study Designed to Assess the Safety, Tolerability and PK of PTI-808 in Healthy Volunteers and in Adults With Cystic Fibrosis).

  9. Drug

    Pacibekitug

    go.drugbank.com/drugs/DB19307
    Investigational

    Human anti-il-6 monoclonal antibody (pf-04236921) is under investigation in clinical trial NCT01405196 (Subcutaneous Treatment in Randomized Subjects to Evaluate Safety and Efficacy in Generalized Lupus

    Synonyms: HUMAN ANTI-IL-6 MONOCLONAL ANTIBODY (PF-04236921)
  10. Drug

    Pumactant

    go.drugbank.com/drugs/DB04955
    Experimental

    It is a unique formulation of the naturally occurring phospholipids Dipalmitoylphosphatidycholine (DPPC) and Phosphatidyl Glycerol (PG).