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Carglumic acid
go.drugbank.com/drugs/DB06775ApprovedInvestigationalCarglumic acid was approved by the U.S. Food and Drug Administration (FDA) on 18 March 2010.
Products: UCEDANE 200 MG DAĞILABİLİR TABLET, 60 ADET, PERLUGA 200 MG DAĞILABİLİR TABLET, 60 ADETRibociclib
go.drugbank.com/drugs/DB11730ApprovedInvestigationalThese proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Ribociclib was approved by the FDA in March 2017 under the brand name Kisqali. … Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6).
Mixtures: Kisqali Femara Co-pack, Kisqali Femara Co-packCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsIxabepilone
go.drugbank.com/drugs/DB04845ApprovedInvestigationalIt has a lactone–lactam modification that minimizes susceptibility to esterase degradation. … It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: IXEMPRA (FOR INJECTION 15 MG), IXEMPRA FOR INJECTION 15 MGDoxazosin
go.drugbank.com/drugs/DB00590ApprovedInvestigational[A180649] It is marketed by Pfizer and was initially approved by the FDA in 1990.[L7285]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: DOKSURA 2 MG TABLET, 20 ADET, DOKSURA 4 MG TABLET, 20 ADETTelithromycin
go.drugbank.com/drugs/DB00976ApprovedBinding occurs simultaneously at to two domains of 23S RNA of the 50S ribosomal subunit, domain II and V, where older macrolides bind only to one. … Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with bacterial protein synthesis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: KETEK ® 400 MGHydroquinone
go.drugbank.com/drugs/DB09526ApprovedInvestigationalIt can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. … Hydroquinone has come under scrutiny due to several complications associated with its use, including dermal irritation, exogenous onchronosis, and carginogenicity.
Mixtures: I-max Lightening 5, Obagi Medical - Nu-Derm System - Normal to Dry - Skin Transformation KitProducts: MELADERM %2 JEL, 50 G, MELADERM %4 JEL, 50 GTafamidis
go.drugbank.com/drugs/DB11644ApprovedInvestigationalTafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives[A27206] developed by FoldRX.[A189717] Tafamidis is structurally similar to diflusinal. … [A189717] Tafamidis was granted an EMA market authorisation on 16 November 2011[L6247] and FDA approval on 3 May 2019.[L11280]
Products: Vyndaqel 20 mg Yumuşak Kapsül, 30 ADET, VYNDAQEL® 20 MG CAPSULABLANDA.Moxonidine
go.drugbank.com/drugs/DB09242ApprovedInvestigationalWithdrawnAs well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome. … Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension.
Synonyms: (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8- quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acidProducts: Normohex 0,2 mg - Filmtabletten, Normohex 0,3 mg - FilmtablettenDronedarone
go.drugbank.com/drugs/DB04855ApprovedInvestigational[A34604,L8699] Dronedarone is a related benzofuran compound to amiodarone but its chemical structure lacks iodine moieties which are associated with amiodarone-induced thyroid problems. … [A34604] Similar to [amiodarone], dronedarone is a multichannel blocker that works to control rhythm and rate in atrial fibrillation.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsSynonyms: N-(2-butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)-methanesulfonamide, N-(2-butyl-3-(p-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamideEslicarbazepine acetate
go.drugbank.com/drugs/DB09119ApprovedInvestigationalEslicarbazepine acetate is a prodrug that is rapidly converted to eslicarbazepine, the primary active metabolite in the body. … Eslicarbazepine's mechanism of action is not well understood, but it is known that it does exert anticonvulsant activity by inhibiting repeated neuronal firing and stabilizing the inactivated state of
Synonyms: (10S)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide, (10S)-5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetateCategories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 Inducers