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Displaying results 1621 - 1630 of 8412 in total
  1. Drug

    Zanubrutinib

    go.drugbank.com/drugs/DB15035
    ApprovedInvestigational

    [A187958] Due to this enhanced selectivity towards BTK, zanubrutinib belongs to the second-generation BTK inhibitor drug group that also includes [acalabrutinib], which was approved by the FDA in 2017. … [A187967] BTK is an enzyme that plays a role in oncogenic signalling pathways, promoting the survival and proliferation of malignant B cells.

    Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates
  2. Drug

    Darvadstrocel

    go.drugbank.com/drugs/DB16581
    ApprovedInvestigationalWithdrawn

    It is indicated for the treatment of complex perianal fistulas in adult patients with non-active or mildly active luminal Crohn’s disease when fistulas have shown an inadequate response to at least one

  3. Drug

    Leflunomide

    go.drugbank.com/drugs/DB01097
    ApprovedInvestigational

    Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many othe...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesSynonyms: alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide
  4. Drug

    Lorlatinib

    go.drugbank.com/drugs/DB12130
    ApprovedInvestigational

    It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-positive non-small cell lung cancer, followed by an expanded approval in 2022 to

    Categories: P-glycoprotein inducers, Cytochrome P-450 Substrates
  5. Drug

    Tirfipiravir

    go.drugbank.com/drugs/DB21648
    Experimental

    The usage of the INN stem '-vir' in the name indicates that Tirfipiravir is a antiviral. Tirfipiravir has a monoisotopic molecular weight of 355.1 Da.

  6. Drug

    Litomeglovir

    go.drugbank.com/drugs/DB21363
    Experimental

    The usage of the INN stem '-vir' in the name indicates that Litomeglovir is a antiviral. Litomeglovir has a monoisotopic molecular weight of 498.19 Da.

  7. Drug

    Lasinavir

    go.drugbank.com/drugs/DB19546
    Experimental

    The usage of the INN stem '-vir' in the name indicates that Lasinavir is a antiviral. Lasinavir has a monoisotopic molecular weight of 659.38 Da.

  8. Drug

    Tomeglovir

    go.drugbank.com/drugs/DB19558
    Experimental

    The usage of the INN stem '-vir' in the name indicates that Tomeglovir is a antiviral. Tomeglovir has a monoisotopic molecular weight of 441.17 Da.

  9. Drug

    Potassium

    go.drugbank.com/drugs/DB14500
    ApprovedInvestigational

    They are available in an assortment of tablet, injection, and other forms, depending on the setting and condition being treated. … Potassium is an essential nutrient, like [Calcium] and [Magnesium]. It was identified as a shortfall nutrient by the 2015-2020 Advisory Committee of Dietary Guidelines for Americans.

    Mixtures: Cal & Mag Hvp Chel Plus C Potass & Zinc Tab, Liquid Opti-minplex +d
  10. Drug

    Tegafur-uracil

    go.drugbank.com/drugs/DB09327
    Approved

    Tegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a molar ratio of 1:4. … It was developed as an anti-cancer therapy by Taiho Pharmaceutical Co Ltd.[A32073] It is approved in different countries but it is not yet approved by the FDA, Health Canada or EMA.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 Substrates