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Exagamglogene autotemcel
go.drugbank.com/drugs/DB15572ApprovedInvestigationalSickle cell disease (SCD) is a genetic disorder characterized by the production of abnormal sickle-shaped red blood cells (called hemoglobin S, HbS) that initiate a pathophysiology resulting in severe … mainstay of treatment since the 1990s - as well as newer agents like [crizanlizumab] and [voxelotor].
Synonyms: gene editing consisting of a guide RNA (gRNA), Autologous CD34+ cells isolated from mobilised peripheral blood by positive selection, modified by CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9) mediatedLNP-nCoVsaRNA Vaccine
go.drugbank.com/drugs/DB15799ExperimentalLNP-nCoVsaRNA is a purified, synthetic mRNA vaccine candidate encoding the S glycoprotein of SARS-CoV-2, which is used primarily by the virus to attach to and invade human cells. … As of July 2020, a clinical trial (COVAC1) is underway (ISRCTN17072692) to test the safety and immunogenicity of the vaccine.
SCB-2019
go.drugbank.com/drugs/DB15805InvestigationalSCB-2019 is a recombinant trimeric S protein subunit vaccine candidate being investigated against COVID-19. … As of June 2020, the company is pursuing a randomized, double blind, placebo controlled study (NCT04405908) to test the safety and immunogenicity of the vaccine.
CoVac-1
go.drugbank.com/drugs/DB16429InvestigationalSponsored by the University Hospital Tuebingen in Germany, CoVac-1 is a multi-peptide COVID-19 vaccine candidate created from HLA class I and HLA-DR T-cell epitopes of the S-protein[A226588]. … T-cell immunity[A226588].
Nabilone
go.drugbank.com/drugs/DB00486ApprovedInvestigationalIt is also approved for use in treatment of anorexia and weight loss in patients with AIDS. Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers. … it is considered to be twice as active as Δ⁹-THC.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsProducts: Canemes 1 mg KapselnLipegfilgrastim
go.drugbank.com/drugs/DB13200ApprovedGranulocyte colony-stimulating factors (G-CSFs) were introduced in the 1980's to the clinical setting to stimulate neutrophil proliferation and differentiation, thereby reducing the duration and severity … Lipegfilgrastim, previously known as XM22, is a pegylated, recombinant granulocyte colony-stimulating factor (G-CSF) that was synthetized using a highly site-specific glycoPEGylation technology [A32665
KBP-COVID-19
go.drugbank.com/drugs/DB15858InvestigationalKBP cloned COVID-19’s genetic sequence, identified a potential antigen, and then inserted it into tobacco plants for reproduction. … As of July 2020, KBP is conducting a Phase 1/2 clinical trial to evaluate the safety and immunogenicity of KBP-COVID-19 vaccine in healthy patients (NCT04473690).
Hydrochlorothiazide
go.drugbank.com/drugs/DB00999ApprovedInvestigationalVet approvedHydrochlorothiazide is the most commonly prescribed thiazide diuretic.[A185138] It is indicated to treat edema and hypertension. … [A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors.
Mixtures: METOPROLOL HCT S 100/12.5, METOPROLOL HCT S 100/12.5Categories: Heterocyclic Compounds, 2-RingCefovecin
go.drugbank.com/drugs/DB11505ExperimentalVet approvedIt is used for the treatment of skin infections caused by Pasturella multocida in cats, and Staphylococcus intermedius/S. canis in dogs. … Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs.
Categories: Heterocyclic Compounds, 2-RingPipamperone
go.drugbank.com/drugs/DB09286InvestigationalIn an effort to improve [haloperidol]'s pharmacological effects, Janssen discovered that pipamperone, an agent whose pharmacological profile was distinct from haloperidol and all other known antipsychotic … Pipamperone is a typical antipsychotic of the _butyrophenone_ family used in the treatment of schizophrenia.