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Zoliflodacin
go.drugbank.com/drugs/DB12817ApprovedInvestigationalGonorrhea, caused by Neisseria gonorrhoeae, presents a significant public health challenge due to increasing antimicrobial resistance. Zoliflodacin is a first-in-class spiropyrimidinetrione antibiotic designed to address this need by inh...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSecnidazole
go.drugbank.com/drugs/DB12834ApprovedInvestigationalSecnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including DB00916 and DB00911, but displays improved oral absorption and a longer terminal elimination half-l...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: SECNIDAZOL 500 MG POLVO P RECONSTRUIR, SECNIDAZOL 750 MG POLVO P. RECOSTRUIRGrapiprant
go.drugbank.com/drugs/DB12836InvestigationalVet approvedGrapiprant, also known as AT-001 and CJ-023, is a drug from the piprant class. These molecules were derived from acylsulfonamide and are characterized to be a novel series of para-N-acylaminomethylbenzoic acid known to be prostaglandin r...
Categories: P-glycoprotein substratesTheodrenaline
go.drugbank.com/drugs/DB12927InvestigationalTheodrenaline is under investigation in clinical trial NCT01311414 (Effect of Cafedrine/Theodrenaline and Urapidil on Cerebral Oxygenation).
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProthipendyl
go.drugbank.com/drugs/DB12958InvestigationalProthipendyl has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesMiocamycin
go.drugbank.com/drugs/DB13287ApprovedMiocamycin is a macrolide type antimicrobial . This drug may be marketed in Japan for clinical use as it is listed in the Japanese pharmacopeia . It has shown to be effective against several gram-positive and gram-negative microbes and m...
Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsDexchlorpheniramine
go.drugbank.com/drugs/DB13679InvestigationalDexchlorpheniramine is a potent S-enantiomer of chlorpheniramine. The salt form dexchlorpheniramine maleate as the active ingredient is available as a prescription drug indicated for adjunctive therapy for allergic and anaphylactic react...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsRufloxacin
go.drugbank.com/drugs/DB13772InvestigationalRufloxacin is a quinolone antibiotic.
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 Enzyme InhibitorsFrovatriptan
go.drugbank.com/drugs/DB00998ApprovedFrovatriptan is a triptan drug developed by Vernalis for the treatment of migraine headaches, in particular those associated with menstruation. Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesLevobupivacaine
go.drugbank.com/drugs/DB01002ApprovedInvestigationalWithdrawnLevobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZeneca under the t...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates