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Displaying results 161 - 170 of 449 in total
  1. Drug

    Eftrenonacog alfa

    go.drugbank.com/drugs/DB11608
    Approved

    It is comprised of a single molecule of human factor IX (FIX) covalently linked to the constant region (Fc) domain of human IgG1 via recombinant DNA technology in a human embryonic kidney cell line (HEK293H … Eftrenonacog alfa is a long-acting recombinant fusion protein used in the treatment of hemophilia B.

    Categories: Immunoglobulins, Immunoglobulin FragmentsSynonyms: Recombinant human coagulation factor IX, FC Fusion protein, Coagulation factor IX recombinant immunoglubulin g1 fusion protein
  2. Drug

    Sotigalimab

    go.drugbank.com/drugs/DB16413
    Investigational

    Sotigalimab is under investigation in clinical trial NCT03123783 (CD40 Agonistic Antibody APX005M in Combination With Nivolumab).

    Synonyms: IMMUNOGLOBULIN G1 (270-GLUTAMIC ACID, C-TERMINAL-LYSINE-CLIPPED), ANTI-(HUMAN CD40 ANTIGEN) (HUMAN-ORYCTOLAGUS CUNICULUS MONOCLONAL APX005M .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-ORYCTOLAGUS CUNICULUS MONOCLONALCategories: Immunoglobulins
  3. Drug

    Efepoetin alfa

    go.drugbank.com/drugs/DB19197
    Investigational

    Efepoetin alfa is under investigation in clinical trial NCT04155125 (A Study of Efepoetin Alfa in Treating Anaemia Associated With Chronic Kidney Diseases Patient).

    Synonyms: Erythropoietin (human) fusion protein with immunoglobulin (synthetic hybrid fc fragment hyfc), Human erythropoietin (epoetin alfa) fused to a hybrid human immunoglobulin (ig), consisting of the fc fragment of the igg4 fused to the hinge and amino-terminus of the igd heavy chain isotype 2, produced
  4. Drug

    Ponsegromab

    go.drugbank.com/drugs/DB18943
    Investigational

    Ponsegromab is under investigation in clinical trial NCT05492500 (A Study of Ponsegromab in People With Heart Failure).

    Synonyms: Immunoglobulin g1 (237-alanine,238-alanine,240-alanine), anti-(human growth differentiation factor 15) (human-mus musculus monoclonal pf-06946860 .gamma.1-chain), disulfide with human-mus musculus monoclonal
  5. Drug

    Dostarlimab

    go.drugbank.com/drugs/DB15627
    ApprovedInvestigational

    Dostarlimab is an IgG<sub>4</sub> humanized monoclonal antibody targeted against the human programmed death receptor-1 (PD-1). … [L33320] PD-1 receptors are found on T-cells and, when activated, serve to inhibit immune responses - some cancers leverage this system by overexpressing PD-1 ligands, thereby effectively inhibiting the

    Categories: Immunoglobulins, Antibodies, Monoclonal, HumanizedSynonyms: Immunoglobulin G4, anti-programmed cell death protein 1 (PDCD1) (humanized clone ABT1 gamma4-chain), disulfide with humanized clone ABT1 kappa-chain, dimer
  6. Drug

    Nofazinlimab

    go.drugbank.com/drugs/DB18852
    Investigational

    Nofazinlimab is under investigation in clinical trial NCT04194775 (A Study of Nofazinlimab (CS1003) in Subjects With Advanced Hepatocellular Carcinoma).

    Synonyms: Immunoglobulin g4 (223-proline), anti-(human programmed cell death protein 1) (human-mus musculus monoclonal cs1003 .gamma.4-chain), disulfide with human-mus musculus monoclonal cs1003 .kappa., Recombinant pd-1 mab cs1003Categories: Immunoglobulins
  7. Drug

    Anselamimab

    go.drugbank.com/drugs/DB17492
    Investigational

    Synonyms: Immunoglobulin g1, anti-(human amyloid fibril) (human-mus musculus monoclonal cael-101 .gamma.1-chain), disulfide with human-mus musculus monoclonal cael-101 .kappa.-chain, dimer, IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS IMMUNOGLOBULIN LIGHT CHAIN AMYLOID (AL) FIBRILS), CHIMERIC MONOCLONAL ANTIBODY (GAMMA1 HEAVY CHAIN CHIMERIC (1-441) (MUS MUSCULUS VH (IGHV2-3*01 (92.6%)-(IGHD
  8. Drug

    Denecimig

    go.drugbank.com/drugs/DB18426
    Investigational

    Synonyms: Immunoglobulin G4 [230-proline,de-449-lysine], anti-(human blood-coagulation factor IX) (human clone 0365-0001-9985 γ4-chain), disulfide with human clone 0365-0001-9985 κ-chain, (228.fwdarw.226′),(231., fwdarw.229′)-bis(disulfide) with anti-(human bl
  9. Drug

    Maplirpacept

    go.drugbank.com/drugs/DB18441
    Investigational

    Maplirpacept is a recombinant fusion protein consisting of the CD47-binding domain of human signal regulatory protein alpha (SIRPa) linked to the IgG4 Fc region of human IgG.

    Synonyms: 1-118-Signal regulatory protein α (human) fusion protein with immunoglobulin G4 [128-proline] (human γ4-chain C region C-terminal fragment), dimer
  10. Drug

    Upanovimab

    go.drugbank.com/drugs/DB16505
    Investigational

    Upanovimab (SCTA01) was under investigation in clinical trials (NCT04683328, NCT04644185, NCT04709328 and NCT05156645) to evaluate its safety and efficacy in patients with severe COVID-19

    Synonyms: IMMUNOGLOBULIN G1, ANTI-(SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 SPIKE GLYCOPROTEIN) (HUMAN-MUS MUSCULUS MONOCLONAL SCTA01 .GAMMA.1-CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL SCTA01 .Categories: Immunoglobulins