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Phenazopyridine
go.drugbank.com/drugs/DB01438ApprovedInvestigationalPhenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during … [L7832] It is still used in various parts of the world. Ingestion of phenazopyridine is found to change the appearance of the urine by imparting an orange or red color, as it is considered an azo dye.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 2,6-Diamino-3-phenylazopyridine, 2,6-Diamino-3-(phenylazo)pyridineGaradacimab
go.drugbank.com/drugs/DB15629ApprovedGaradacimab is a fully human monoclonal antibody targeted against activated factor XII. … [L53303,L53283] It is the first inhibitor of factor XIIa to receive market approval.[L53303]
Chymopapain
go.drugbank.com/drugs/DB06752ApprovedWithdrawnIt is currently discontinued.[L2487] … [L2482]It is an extracellular plant cysteine proteinase similar to papain in specificity.[A32688] Chymopapain was developed by Chart Medcl and FDA approved on November 10, 1982.
Products: Chymodiactin Injection - 4 Nkat Units/2mlGivosiran
go.drugbank.com/drugs/DB15066ApprovedGivosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. … [L10202] It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a genetic disorder
Categories: Heterocyclic Compounds, 1-Ring, Aminolevulinate Synthase 1-directed RNA InteractionCholecystokinin
go.drugbank.com/drugs/DB08862ApprovedInvestigationalWithdrawnCholecystokinin ( also known as _CCK or CCK-PZ_) is a peptide hormone of the gastrointestinal system which is responsible for stimulating the digestion of fat and protein. … Recent studies have suggested that cholecystokinin also plays a major role in inducing drug tolerance to opioids such as morphine and heroin, and is partially implicated in experiences of pain hypersensitivity
Sobuzoxane
go.drugbank.com/drugs/DB21119ExperimentalSobuzoxane is a small molecule drug. The usage of the INN stem '-oxan(e)' in the name indicates that Sobuzoxane is a benzodioxane derivative. … Sobuzoxane has a monoisotopic molecular weight of 514.23 Da.
Categories: Topoisomerase II Inhibitors, Heterocyclic Compounds, 1-RingPhentermine
go.drugbank.com/drugs/DB00191ApprovedIllicitInvestigationalPhentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug. … [A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine.
Categories: Cytochrome P-450 Substrates, Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesProducts: Adipex-P, TERFAMEX TProfenamine
go.drugbank.com/drugs/DB00392ApprovedProfenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism. … It is sold under the trade name Parsitan in Canada.[L46812] In the US, the marketing of profenamine has been discontinued.[L46817]
Categories: Heterocyclic Compounds, 3-RingSynonyms: N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine, 2-diethylamino-1-propyl-N-dibenzoparathiazineDonanemab
go.drugbank.com/drugs/DB16647ApprovedInvestigationalDonanemab is a humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against insoluble N-truncated pyroglutamate amyloid beta (Aβ), [L50978] which is found in the brain amyloid plaques that … [A232214] On July 2, 2024, donanemab was approved by the FDA for the treatment of AD in patients with mild cognitive impairment or dementia symptoms.
Synonyms: Immunoglobulin G1, anti-(human pyroglutamyl Aβ (3-x) peptide)(human clone LY3002813 γ1-chain), disulfide with human clone LY3002813 κ-chain, dimer, IMMUNOGLOBULIN G1-KAPPA, ANTI-(HOMO SAPIENS APP (AMYLOID BETA A4 PRECURSOR PROTEIN) A BETA 3-PYROGLUTAMYL PEPTIDES, A.BETA. 3 (3-X)), HUMANIZED MONOCLONAL ANTIBODYGAMMA1 HEAVY CHAIN HUMANIZED (1-444) (Dimethicone 410
go.drugbank.com/drugs/DB14005ApprovedDimethicone is a silicone-based polymer used as a moisturizer in different skin OTC products.[A32462] It is formed by repeated polymeric units of -(CH3)2SiO- with a terminal trimethyl siloxy unit. … [L1769] It is currently recognized by the FDA as a skin protectant OTC ingredient for human use in a concentration of 1-30%.