Phenazopyridine is a local anesthetic used for the symptomatic relief of pain, burning, urgency, frequency, and general discomfort caused by lower urinary tract irritations that are a result of infection, trauma, surgery, endoscopic procedures, or the passage of equipment or catheters. Phenazopyridine, also known as Pyridium, is a urinary tract analgesic used for the short-term management of urinary tract irritation and its associated unpleasant symptoms such as burning and pain during urination.
- Mechanism
- Curator reviewed · 4 references
The full mechanism of action of phenazopyridine is not fully elucidated, however, it is reported to exert a direct topical analgesic effect on the mucosal lining of the urinary tract via the inhibition of voltage-gated sodium channels and possibly group A nerve fibers, as suggested by the results of a study in rats. The above actions likely lead to the relief of unpleasant urinary symptoms.
- Primary indication
- Phenazopyridine hydrochloride is indicated to relieve uncomfortable symptoms that occur as a consequence of mucosal irritation of the lower urinary tract in adults.Curator reviewed · 2 structured indications
- Formula / weight
- C11H11N5 · 213.2385 g/mol (avg)
- First approval
- Canada, 2020 · United States, 2005
- Brand names
Resolves to
QPFYXYFORQJZEC-FOCLMDBBSA-NSMILESNC1=NC(N)=C(C=C1)\N=N\C1=CC=CC=C1What you can answer from here — as of August 31, 2026
Which drugs share a target with Phenazopyridine, and which of those have an active Phase 3 trial?
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