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Motixafortide
go.drugbank.com/drugs/DB14939ApprovedInvestigational[L48136] Similar in mechanism to the previously approved [plerixafor], motixafortide is an inhibitor of C-X-C Motif Chemokine Receptor 4 (CXCR4), a protein that helps to anchor stem cells to bone marrow … Motixafortide is a cyclic peptide hematopoietic stem cell mobilizer used to improve stem cell collection prior to autologous transplantation.
Crizanlizumab
go.drugbank.com/drugs/DB15271ApprovedInvestigational[A187904] Though hydroxyurea has been shown to reduce the frequency of vaso-occlusive crises, adherence to this therapy is difficult due to adverse effects and the high variability of response to the drug … The genetic mutation associated with this disease leads to the formation of abnormal, sickle shaped red blood cells that aggregate and block blood vessels throughout the body, causing vaso-occlusive crises
Migalastat
go.drugbank.com/drugs/DB05018ApprovedInvestigationalThis enzyme is responsible for breaking down glycosphingolipid substrate that, when deficient in patients with Fabry disease, builds up in the blood vessels, the kidneys, the nerves, the heart, and other … [L47036,L47057,L4274,L4278] A further study is required to verify and describe the clinical benefits of Galafold, and the sponsor will be conducting a confirmatory clinical trial of Galafold in adults
Calcitriol
go.drugbank.com/drugs/DB00136ApprovedInvestigationalNutraceuticalto [DB00146] in the liver and kidneys. … tubular reabsorption of calcium in the kidneys, and stimulating the release of calcium stores from the skeletal system.
Synonyms: (1S,3R,5Z,7E)-9,10-secocholesta-5,7,10-triene-1,3,25-triol, (1α,3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triolProducts: ROCALTROL CAPSULAS DE GELATINA BLANDA0.25MCG, ROCALTROL® 0.50 CÁPSULAS DE GELATINA BLANDA 0.50 MCG.Pralidoxime
go.drugbank.com/drugs/DB00733ApprovedInvestigationalVet approvedOrganophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. … If given within 24 hours,after organophosphate exposure, pralidoxime reactivates the enzyme cholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase
Vortioxetine
go.drugbank.com/drugs/DB09068ApprovedInvestigationalreceptor, an agonist of 5-HT1A, and an antagonist of the 5-HT3, 5-HT1D, and 5-HT7 receptors. … More specifically, vortioxetine acts via the following biological mechanisms: as a serotonin reuptake inhibitor (SRI) through inhibition of the serotonin transporter, as a partial agonist of the 5-HT1B
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, Serotonin Receptor AgonistsTemazepam
go.drugbank.com/drugs/DB00231ApprovedIn particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to … Although the chemical synthesis of temazepam was established by 1965 [A175333], mainstream contemporary use of the medication did not occur until it's legitimate use as treatment for insomnia was accepted
Resmetirom
go.drugbank.com/drugs/DB12914ApprovedInvestigationalOn March 14, 2024, it was approved by the FDA as the first treatment of liver fibrosis due to noncirrhotic non-alcoholic steatohepatitis (NASH), which is a form of non-alcoholic fatty liver disease (NAFLD … Resmetirom is a thyroid hormone receptor-beta (THR-beta) agonist.
Categories: Thyroid Hormone Receptor beta Agonist, Thyroid hormone receptor-beta (THR-beta) agonistSelexipag
go.drugbank.com/drugs/DB11362ApprovedInvestigationalMarketed by Actelion Pharmaceuticals under brand name Uptravi, selexipag and its active metabolite, ACT-333679 (MRE-269), act as agonists of the prostacyclin receptor to increase vasodilation in the pulmonary … circulation and decrease elevated pressure in the blood vessels supplying blood to the lungs.
Categories: Prostacyclin Receptor Agonist, Prostacyclin Receptor AgonistsPhenelzine
go.drugbank.com/drugs/DB00780ApprovedInvestigationalIt is currently approved under prescription by the name of Nardil. … Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome