Pralidoxime is a cholinesterase reactivator used to treat organophosphate poisoning. Pralidoxime is an antidote to organophosphate pesticides and chemicals.
- Mechanism
- Curator reviewed
Pralidoxime is an antidote to organophosphate pesticides and chemicals. Organophosphates bind to the esteratic site of acetylcholinesterase, which results initially in reversible inactivation of the enzyme. Acetylcholinesterase inhibition causes acetylcholine to accumulate in synapses, producing continuous stimulation of cholinergic fibers throughout the nervous systems. If given within 24 hours after organophosphate exposure, pralidoxime reactivates the acetylcholinesterase by cleaving the phosphate-ester bond formed between the organophosphate and acetylcholinesterase.
- Primary indication
- For the treatment of poisoning due to those pesticides and chemicals of the organophosphate class which have anticholinesterase activity and in the control of overdosage by anticholinesterase drugs used in the treatment of myasthenia gravis.Curator reviewed · 3 structured indications
- Formula / weight
- C7H9N2O · 137.1592 g/mol (avg)
- First approval
- Canada, 2003 · United States, 1965
- Also known as
- 2-PAM
- Code names
- NSC 164614
- Brand names
Resolves to
JBKPUQTUERUYQE-UHFFFAOYSA-OSMILESC[N+]1=C(\C=N\O)C=CC=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Pralidoxime, and which of those have an active Phase 3 trial?
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