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Brinzolamide
go.drugbank.com/drugs/DB01194ApprovedBrinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase II (CA-II) inhibitor indicated to reduce ocular pressure in patients with ocular hypertension or open-angle glaucoma. … [A2049,A2051] Although systemic anti-carbonic anhydrase (CA) therapy has been used for almost 50 years with varying degrees of success, systemic administration results in an increase in incidences of adverse
Fludrocortisone
go.drugbank.com/drugs/DB00687ApprovedInvestigationalFludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency. … [A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to [cortisol], differing only by a fluorine atom at the 9-position
Categories: Corticosteroids for Systemic Use, Corticosteroids for Systemic Use, PlainIdebenone
go.drugbank.com/drugs/DB09081ApprovedInvestigationalLack of improvement in cognitive function halted its production for these conditions, however it continues to be investigated for use in other conditions associated with mitochondrial damage. … It is not currently approved for use by either the Food and Drug Administration (USA) or Health Canada.
Categories: Compounds used in a research, industrial, or household setting, Psychostimulants, Agents Used for ADHD and NootropicsPepsin
go.drugbank.com/drugs/DB13198ApprovedWithdrawnPepsin is approved by the FDA and is used in food at levels not to exceed current good manufacturing practice [L2363]. … Studies on gastric digestion from 1820-1840 led to the discovery of pepsin as the substance which, in the presence of stomach acid, causes nutrients including meat or coagulated egg whites to dissolve.
Mixtures: Neo Life Enzyme Tab, Neo Life Beta Gest TabAdenosine phosphate
go.drugbank.com/drugs/DB00131ApprovedInvestigationalNutraceuticalWithdrawnAdenosine phosphate was withdrawn by the FDA since it was considered neither safe nor effective for its intended uses as a vasodilator and an anti-inflammatory.[L43937] … Adenosine phosphate, or adenylic acid, is an adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.
Synonyms: 5'-O-PhosphonoadenosineGaradacimab
go.drugbank.com/drugs/DB15629Approved[A273993] In June 2025, garadacimab was approved by the US FDA for the prophylaxis of HAE episodes in patients ≥12 years of age. … [A273993,A273998] As opposed to [lanadelumab], another prophylactic agent for HAE that targets kallikrein, garadacimab targets activated factor XII, the first factor in the contact system responsible for
Categories: Drugs Used in Hereditary AngioedemaSotorasib
go.drugbank.com/drugs/DB15569ApprovedInvestigational[A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer.[L34288] This mutation makes up >50% of all KRAS mutations. … [A187547] The drug [MRTX849] is also currently being developed and has the same target.
Foreskin keratinocyte (neonatal)
go.drugbank.com/drugs/DB10772ApprovedIn 1981, O’Conner and his group utilized cultured autologous epithelium to coat burn defects for the first time. … It is used for grafting onto partial-thickness wounds, where it offers a favorable matrix for host cell migration [L2452].
Mitogen-activated protein kinase kinase kinase 19
go.drugbank.com/bio_entities/BE0009408TargetHumansSynonyms: Regulated in COPD, protein kinaseNevirapine
go.drugbank.com/drugs/DB00238ApprovedInvestigationalA potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. … Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.
Mixtures: ZIMODINE N ®, LAVUZID® NCategories: Antivirals used in combination for the treatment of HIV infections, Antivirals for Systemic Use