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Displaying results 1861 - 1870 of 10000 in total
  1. Drug

    Garadacimab

    go.drugbank.com/drugs/DB15629
    Approved

    [A273993] In June 2025, garadacimab was approved by the US FDA for the prophylaxis of HAE episodes in patients ≥12 years of age. … [A273993,A273998] As opposed to [lanadelumab], another prophylactic agent for HAE that targets kallikrein, garadacimab targets activated factor XII, the first factor in the contact system responsible for

    Categories: Drugs Used in Hereditary Angioedema
  2. Drug

    Sotorasib

    go.drugbank.com/drugs/DB15569
    ApprovedInvestigational

    [A187547,A187556] It is indicated in the treatment of adult patients with KRAS G12C mutant non-small cell lung cancer.[L34288] This mutation makes up >50% of all KRAS mutations. … [A187547] The drug [MRTX849] is also currently being developed and has the same target.

  3. Drug

    Lonapegsomatropin

    go.drugbank.com/drugs/DB16220
    ApprovedInvestigational

    Lonapegsomatropin, also known as TransCon hGH or ACP 001, is a methoxypegylated prodrug of human growth hormone ([somatropin]) indicated for the treatment of children 1 year and older, weighing at least … [L36380,L10971] Lonapegsomatropin was granted FDA approval on 25 August 2021.[L36380] It was later approved by the European Commission on 13 January 2022.[L39900]

  4. Drug

    Foreskin keratinocyte (neonatal)

    go.drugbank.com/drugs/DB10772
    Approved

    In 1981, O’Conner and his group utilized cultured autologous epithelium to coat burn defects for the first time. … It is used for grafting onto partial-thickness wounds, where it offers a favorable matrix for host cell migration [L2452].

  5. Drug

    Niraparib

    go.drugbank.com/drugs/DB11793
    ApprovedInvestigational

    Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. … [A253248] First approved by the FDA on March 27, 2017,[A253912] niraparib is used to treat epithelial ovarian, fallopian tube, or primary peritoneal cancer.

  6. Target

    Mitogen-activated protein kinase kinase kinase 19

    go.drugbank.com/bio_entities/BE0009408
    TargetHumans

    Synonyms: Regulated in COPD, protein kinase
  7. Drug

    Nevirapine

    go.drugbank.com/drugs/DB00238
    ApprovedInvestigational

    A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. … Structurally, nevirapine belongs to the dipyridodiazepinone chemical class.

    Mixtures: ZIMODINE N ®, LAVUZID® NCategories: Antivirals used in combination for the treatment of HIV infections, Antivirals for Systemic Use
  8. Drug

    Dutasteride

    go.drugbank.com/drugs/DB01126
    ApprovedInvestigational

    Dutasteride was approved by the FDA in 2001 for the treatment of symptomatic benign prostatic hyperplasia (BPH) in men as monotherapy or in combination with the α-adrenergic antagonist [tamsulosin] to … However, unlike finasteride, dutasteride is not yet indicated for the treatment of androgenic alopecia although it was demonstrated to be effective in several randomized, double-blind, placebo-controlled

    Categories: Drugs Used in Benign Prostatic HypertrophySynonyms: (5α,17β)-N-(2,5-bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
  9. Drug

    Trandolapril

    go.drugbank.com/drugs/DB00519
    ApprovedInvestigational

    It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. … for congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.

    Categories: Agents Acting on the Renin-Angiotensin System, Antihypertensive Agents Indicated for Hypertension
  10. Drug

    Lanolin

    go.drugbank.com/drugs/DB11112
    Approved

    For this reason, it is also called wool wax or wool grease. Lanolin is used in the protection, treatment, and cosmetic enhancement of human skin. … Lanolin is also frequently used in protective baby skin treatment and for sore nipples in breastfeeding mothers [L2583], [A32788].

    Mixtures: Kendra SKIN PROTECTION and PAIN RELIEF FOR HAIR REMOVAL, Skullduggery Pain Relief and Skin Protection for TattoosCategories: Compounds used in a research, industrial, or household setting