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Lanifibranor
go.drugbank.com/drugs/DB14801InvestigationalLanifibranor is under investigation in clinical trial NCT03008070 (Phase 2b Study in NASH to Assess IVA337).
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingONO-2952
go.drugbank.com/drugs/DB14802Investigationalinvestigation in clinical trial NCT01887002 (Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
AMY-101
go.drugbank.com/drugs/DB14803InvestigationalAMY-101, also known as compstatin 40, is a peptidic inhibitor of the central complement component C3. … AMY-101 is under investigation in clinical trial NCT03694444 (A Study of the C3 Complement Inhibitor AMY-101 in Adults With Gingivitis).
Synonyms: S3,S13-Cyclo(D-tyrolsyl-L-isoleucyl-L-cysteinyl-L-valyl-1-methyl-L-tryptophyl-L-glutaminyl-L-aspartyl-L-tryptophyl-N-methyl-L-glycyl-L-alanyl-L-histidyl-L-arginyl-L-cysteinyl-N-methyl-L-isoleucinamide)Iodine I-125
go.drugbank.com/drugs/DB14804InvestigationalIodine I-125 is under investigation in clinical trial NCT00079417 (Neoadjuvant Carboplatin and Vincristine and Standard Local Ophthalmic Therapy in Treating Patients With Intraocular Retinoblastoma).
Synonyms: Iodine I-125PF-232798
go.drugbank.com/drugs/DB14813InvestigationalPF-232798 is under investigation in clinical trial NCT01140425 (Study To Evaluate The Effect Of A Multiple Oral Dose Of PF-00232798 On QT Intervals In Healthy Subjects).
Categories: Heterocyclic Compounds, 1-RingLanabecestat
go.drugbank.com/drugs/DB14814InvestigationalLanabecestat is under investigation in clinical trial NCT03499041 (A Study of LY3314814 in Participants With Liver Impairment).
Categories: Heterocyclic Compounds, 1-RingGinsenoside B2
go.drugbank.com/drugs/DB14815InvestigationalGinsenoside B2 is under investigation in clinical trial NCT00781534 (A Clinical Trial of Ginseng in Diabetes).
SB-649868
go.drugbank.com/drugs/DB14822InvestigationalSB-649868 is under investigation in clinical trial NCT01030939 (Study to Investigate Safety, Tolerability, Pharmacokinetics and Cardiac Function After Repeat Doses of SB-649868 in Healthy-volunteers).
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingCentanafadine
go.drugbank.com/drugs/DB14841ApprovedInvestigationalCentanafadine is a reuptake inhibitor at the norepinephrine, dopamine, and serotonin transporters and a central nervous system stimulant. … reuptake inhibitor, positioning it as a new mechanistic option in a condition where response varies widely between individuals and many patients remain symptomatic on existing treatment.
Filgotinib
go.drugbank.com/drugs/DB14845ApprovedInvestigational(IL-6) blockers, and tumor necrosis factor (TNF) inhibitors. … In contrast, the newly approved filgotinib is a highly selective JAK1 inhibitor.
Categories: P-glycoprotein substrates, Heterocyclic Compounds, 1-Ring